SEARCHSYSTEMATIC_REVIEWinfectious disease, preclinical research

systematic_review·infectious disease, preclinical research, biomedical research, research methods·PMC10451389

Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance

Antibiotics · 7 authors, 4 centres

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TL;DR

This review examines the historical use and modern applications of silver nanoparticles (AgNPs) as antibacterial agents, focusing on their mechanisms, physicochemical properties, and potential synergy with antibiotics against resistant pathogens.

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This narrative review synthesizes preclinical research on silver nanoparticles (AgNPs) as antibacterial agents. It details the history of silver use, methods for AgNP fabrication, their physicochemical properties, and antibacterial mechanisms against Gram-positive and Gram-negative bacteria, with emphasis on ESKAPE pathogens. The review highlights how AgNP-antibiotic conjugates can synergistically reduce pathogen growth, potentially allowing lower antibiotic doses to mitigate resistance. The authors conclude that despite strong research on efficacy, more work is needed on reproducibility, characterization, and understanding organ effects before mass clinical deployment.

STUDY TYPE

systematic_review

SPECIALTY

infectious disease

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10451389

Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance

Antibiotics

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ABSTRACT

Antibiotic resistance in bacteria is a major problem worldwide that costs 55 billion USD annually for extended hospitalization, resource utilization, and additional treatment expenditures in the United States. This review examines the roles and forms of silver (e.g., bulk Ag, silver salts (AgNO 3 ), and colloidal Ag) from antiquity to the present, and its eventual incorporation as silver nanoparticles (AgNPs) in numerous antibacterial consumer products and biomedical applications. The AgNP fabrication methods, physicochemical properties, and antibacterial mechanisms in Gram-positive and Gram-negative bacterial models are covered. The emphasis is on the problematic ESKAPE pathogens and the antibiotic-resistant pathogens of the greatest human health concern according to the World Health Organization. This review delineates the differences between each bacterial model, the role of the physicochemical properties of AgNPs in the interaction with pathogens, and the subsequent damage of AgNPs and Ag + released by AgNPs on structural cellular components. In closing, the processes of antibiotic resistance attainment and how novel AgNP–antibiotic conjugates may synergistically reduce the growth of antibiotic-resistant pathogens are presented in light of promising examples, where antibiotic efficacy alone is decreased.

CITATION EXPORT

Kyra G. Kaiser, Victoire Delattre, Victoria J. Frost et al.. Nanosilver: An Old Antibacterial Agent with Great Promise in the Fight against Antibiotic Resistance. Antibiotics. (2023). https://doi.org/10.3390/antibiotics12081264

AUTHORS

7 · 4 CENTRES

Kyra G. Kaiser, Victoire Delattre, Victoria J. Frost, Gregory W. Buck, Julianne V. Phu, Timea G. Fernandez, Ioana E. Pavel

1Department of Physical and Environmental Sciences, Texas A&M University Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, USA; [email protected] (K.G.K.); [email protected] (V.D.); [email protected] (G.W.B.)
2Department of Life Sciences, Texas A&M University Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, USA
3Department of Chemistry, Physics, Geology and the Environment, Winthrop University, 701 Oakland Avenue, Rock Hill, SC 29733, USA; [email protected] (V.J.F.); [email protected] (J.V.P.)
4Department of Biology, Winthrop University, 701 Oakland Avenue, Rock Hill, SC 29733, USA

EDITOR / REVIEWER

Ana Olívia De Souza, Gabriel Padilla