SEARCHNARRATIVE_REVIEWendocrinology, cardiology

narrative_review·endocrinology, cardiology, oncology, biomedical research, systematic review·PMC10279840

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Heliyon · 8 authors, 9 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review summarizes preclinical and clinical evidence on natural products as potential treatments for metabolic disorders like diabetes, obesity, heart disease, and cancer.

Full summary

312 CHARS

This comprehensive narrative review examines the role of inflammation in metabolic disorders and the potential of natural products as therapeutic agents. The review also lists potential biological targets for drug discovery and discusses drug delivery strategies to enhance the bioavailability of phytochemicals.

STUDY TYPE

narrative_review

SPECIALTY

endocrinology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10279840

Natural products targeting inflammation-related metabolic disorders: A comprehensive review

Heliyon

READ THE FULL PAPER

ABSTRACT

Abstract Currently, the incidence of metabolic disorders is increasing, setting a challenge to global health. With major advancement in the diagnostic tools and clinical procedures, much has been known in the etiology of metabolic disorders and their corresponding pathophysiologies. In addition, the use of in vitro and in vivo experimental models prior to clinical studies has promoted numerous biomedical breakthroughs, including in the discovery and development of drug candidates to treat metabolic disorders. Indeed, chemicals isolated from natural products have been extensively studied as prospective drug candidates to manage diabetes, obesity, heart-related diseases, and cancer, partly due to their antioxidant and anti-inflammatory properties. Continuous efforts have been made in parallel to improve their bioactivity and bioavailability using selected drug delivery approaches. Here, we provide insights on recent progress in the role of inflammatory-mediated responses on the initiation of metabolic disorders, with particular reference to diabetes mellitus, obesity, heart-related diseases, and cancer. In addition, we discussed the prospective role of natural products in the management of diabetes, obesity, heart-related diseases, and cancers and provide lists of potential biological targets for high throughput screening in drug discovery and development. Lastly, we discussed findings observed in the preclinical and clinical studies prior to identifying suitable approaches on the phytochemical drug delivery systems that are potential to be used in the treatment of metabolic disorders.

CITATION EXPORT

Firzan Nainu, Andri Frediansyah, Sukamto S Mamada et al.. Natural products targeting inflammation-related metabolic disorders: A comprehensive review. Heliyon. (2023). https://doi.org/10.1016/j.heliyon.2023.e16919

AUTHORS

8 · 9 CENTRES

Firzan Nainu, Andri Frediansyah, Sukamto S Mamada, Andi Dian Permana, Mirnawati Salampe, Deepak Chandran, Talha Bin Emran, Jesus Simal-Gandara

aDepartment of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia
bResearch Center for Food Technology and Processing (PRTPP), National Research and Innovation Agency (BRIN), Yogyakarta 55861, Indonesia
cDepartment of Pharmaceutical Science and Technology, Faculty of Pharmacy, Hasanuddin University, Tamalanrea, Makassar 90245, Indonesia
dSekolah Tinggi Ilmu Farmasi Makassar, Makassar 90242, Indonesia
eDepartment of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, India
fDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI 02912, USA
gDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh
hDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
iUniversidade de Vigo, Nutrition and Bromatology Group, Analytical Chemistry and Food Science Department, Faculty of Science, E32004 Ourense, Spain