SEARCHOTHERpublic health, epidemiology

other·public health, epidemiology, research methods, systematic review, biomedical research·PMC10008260

Neighbourhood environment as a risk factor for adverse health outcomes through association with the microbiome: protocol for a scoping review

BMJ Open · 7 authors, 3 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This paper outlines the protocol for a scoping review that will investigate the relationships between neighbourhood environments and human microbiome diversity to explain associated health outcomes.

Full summary

1,024 CHARS

This paper presents a protocol for a scoping review aiming to explore evidence linking neighbourhood environments to human microbiome diversity and subsequent health outcomes. The methods are based on Arksey and O’Malley’s framework and Page et al’s 2020 PRISMA-ScR workflow. The planned search will cover multiple databases (e.g., PubMed, Embase) using pre-defined MeSH terms for neighbourhood, microbiome, and individual characteristics, with no date or language restrictions. Inclusion requires studies evaluating the relationship between microbiome diversity and neighbourhood with at least one measurement for each. The review process involves iterative screening by two reviewers, risk of bias assessment using tools like ROBINS-I and Cochrane RoB, and consultation with a community advisory board. The analysis will include both qualitative thematic analysis and quantitative descriptive statistics. The primary implication is the potential to identify research gaps and mechanistic pathways for future investigation.

STUDY TYPE

other

SPECIALTY

public health

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10008260

Neighbourhood environment as a risk factor for adverse health outcomes through association with the microbiome: protocol for a scoping review

BMJ Open

READ THE FULL PAPER

ABSTRACT

Abstract Introduction The connection of the microbiome to human health intersects with the physical environment of humans. Each microbiome location can be influenced by environmental conditions that relate to specific geographical locations, which in turn are influenced by social determinants of health such as a neighbourhood. The objective of this scoping review is to explore the current evidence on the relationships between microbiome and neighbourhood to explain microbiome-related health outcomes. Methods and analysis Arksey and O’Malley’s literature review framework will be employed throughout the process, as well as Page, et al ’s 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis updated workflow to process search results. The literature search will be completed using PubMed/Medline (NLM), Embase (Elsevier), Web of Science, Core Collection (Clarivate Analytics), Scopus (Elsevier), medRxiv preprint server and Open Science Framework server. The search will be conducted using a list of pre-identified Medical Subject Headings (MeSH) terms relating to neighbourhood, microbiome and individual characteristics. There will be no date or language restrictions used in the search. In order to be included in the study, a piece must include an evaluation of the relationship between microbiome diversity and neighbourhood (including at least one measurement of the neighbourhood and at least one human microbiome site). Excluded from the review will be those works that do not include all of these measures, literature reviews based on secondary sources and postmortem populations with no report of premortem health factors. The review itself will be an iterative process completed by two reviewers, with a third individual identified to break ties. Documents will be undergoing a risk assessment of bias in order for the authors to comment on the quality of the literature in this area. Finally, results will be discussed with identified stakeholders, including individuals connected to neighbourhoods facing structural inequity and experts in the topics of study through a community advisory board, for their feedback and knowledge transfer. Ethics and dissemination This review does not require ethical approval. Results of this search will be disseminated through peer-reviewed publications. Furthermore, this work is completed in conjunction with a community advisory board so as to ensure dissemination to multiple stakeholders. Keywords: PUBLIC HEALTH, SOCIAL MEDICINE, PREVENTIVE MEDICINE

CITATION EXPORT

Nicole Farmer, Alyssa Baginski, Jenna Alkhatib et al.. Neighbourhood environment as a risk factor for adverse health outcomes through association with the microbiome: protocol for a scoping review. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2022-066913

AUTHORS

7 · 3 CENTRES

Nicole Farmer, Alyssa Baginski, Jenna Alkhatib, Katherine A Maki, Yvonne Baumer, Tiffany M Powell-Wiley, Gwenyth R Wallen

1Translational Biobehavioral and Health Disparities Branch, National Institutes of Health Clinical Center, Bethesda, Maryland, USA
2The Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart Lung and Blood Institute, Bethesda, Maryland, USA
3Intramural Research Program, National Institute on Minority Health and Health Disparities, Bethesda, Maryland, USA