SEARCHCOHORTpediatrics, neurology

cohort·pediatrics, neurology, psychiatry, endocrinology, preclinical research·PMC10642175

Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight

Frontiers in Psychiatry · 12 authors, 6 centres

AI SUMMARY

FIDELITY 100%

POPULATIONAdolescent girls aged 12-17 years with BMI >85th percentile, with or without loss-of-control eating

INTERVENTIONAffective dot-probe attention bias task during magnetoencephalography with angry, happy, and neutral face cues

COMPARISONGirls with loss-of-control eating (N=13) versus girls without loss-of-control eating (N=21)

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This pilot MEG study of 34 adolescent girls with overweight or obesity compared neural responses to emotional face cues between those with and without loss-of-control eating. Girls with loss-of-control eating showed a stronger visual cortex response to angry faces, while the overall sample showed a blunted left dorsolateral prefrontal response to angry versus neutral faces.

Full summary

990 CHARS

This pilot study used magnetoencephalography during an affective dot-probe task to examine neural correlates of attention bias to social threat in 34 adolescent girls (mean age 15.5 ± 1.5 years; BMI-z = 1.7 ± 0.4) with overweight or obesity, of whom 13 exhibited loss-of-control (LOC) eating. Girls with LOC-eating showed a stronger right occipital evoked response to angry faces compared with girls without LOC-eating (F(1, 32) = 16.38, p = 0.0003). Behavioral reaction time bias scores did not differ between groups. Several interactions between evoked neural responses and test-meal macronutrient intake were reported as marginal at p = 0.01 and did not reach corrected significance. The authors interpret the findings as preliminary evidence that altered neural engagement of executive control and visual attention regions to social threat may relate to disinhibited eating, though limitations include the small, homogeneous sample and absence of corrected-significance intake findings.

PICO

PPOPULATION

Adolescent girls aged 12-17 years with BMI >85th percentile, with or without loss-of-control eating

IINTERVENTION

Affective dot-probe attention bias task during magnetoencephalography with angry, happy, and neutral face cues

OOUTCOME

Evoked neural responses in predefined regions of interest and laboratory test meal energy/macronutrient intake

STUDY TYPE

cohort

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10642175

Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight

Frontiers in Psychiatry

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ABSTRACT

Abstract Introduction Loss-of-control (LOC) eating, a key feature of binge-eating disorder, may relate attentional bias (AB) to highly salient interpersonal stimuli. The current pilot study used magnetoencephalography (MEG) to explore neural features of AB to socially threatening cues in adolescent girls with and without LOC-eating. Methods Girls (12–17 years old) with overweight or obesity (BMI >85th percentile) completed an AB measure on an affective dot-probe AB task during MEG and evoked neural responses to angry or happy (vs. neutral) face cues were captured. A laboratory test meal paradigm measured energy intake and macronutrient consumption patterns. Results Girls ( N = 34; M age = 15.5 ± 1.5 years; BMI- z = 1.7 ± 0.4) showed a blunted evoked response to the presentation of angry face compared with neutral face cues in the left dorsolateral prefrontal cortex, a neural region implicated in executive control and regulation processes, during attention deployment ( p < 0.01). Compared with those without LOC-eating ( N = 21), girls with LOC-eating ( N = 13) demonstrated a stronger evoked response to angry faces in the visual cortex during attention deployment ( p < 0.001). Visual and cognitive control ROIs had trends suggesting interaction with test meal intake patterns among girls with LOC-eating ( p s = 0.01). Discussion These findings suggest that girls with overweight or obesity may fail to adaptively engage neural regions implicated in higher-order executive processes. This difficulty may relate to disinhibited eating patterns that could lead to excess weight gain. Keywords: loss-of-control eating, obesity, adolescents, attention bias, binge-eating, magnetoencephalography

CITATION EXPORT

Meghan E Byrne, Marian Tanofsky-Kraff, Lucrezia Liuzzi et al.. Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight. Frontiers in Psychiatry. (2023). https://doi.org/10.3389/fpsyt.2023.1276300

AUTHORS

12 · 6 CENTRES

Meghan E Byrne, Marian Tanofsky-Kraff, Lucrezia Liuzzi, Tom Holroyd, Megan N Parker, Bess F Bloomer, Allison Nugent, Sheila M Brady, Shanna B Yang, Sara A Turner, Daniel S Pine, Jack A Yanovski

1Section on Development and Affective Neuroscience, Emotion and Development Branch, National Institute of Mental Health (NIMH), Bethesda, MD, United States
2Division of Intramural Research, National Institutes of Health (NIH), Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States
3Department of Medical and Clinical Psychology, USUHS, Bethesda, MD, United States
4Military Cardiovascular Outcomes Research (MiCOR) Program, Department of Medicine, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, United States
5MEG Core Facility, National Institute of Mental Health (NIMH), Bethesda, MD, United States
6Nutrition Department, Clinical Center, NIH, Bethesda, MD, United States