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TL;DR
Targeting metabolic pathways such as glycolysis and the polyol pathway may help restore neutrophil function and reduce infection susceptibility in T2D.
Human Cell · 5 authors, 1 centre
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Targeting metabolic pathways such as glycolysis and the polyol pathway may help restore neutrophil function and reduce infection susceptibility in T2D.
The authors describe how nutrient excess in T2D, including hyperglycemia and elevated lipids, dysregulates metabolic pathways such as glycolysis, the pentose phosphate pathway, glutaminolysis, and the polyol pathway. These alterations lead to constitutive neutrophil activation with impaired effector responses, including reduced NET formation, decreased phagocytic activity, and abnormal ROS production. Inhibitors targeting aldose reductase and other metabolic enzymes are discussed as potential strategies. The authors conclude that therapeutic approaches beyond glucose lowering may be needed due to metabolic memory.