Pharmaceutics · 6 authors, 3 centres
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This narrative review evaluates three-dimensional (3D) cell culture platforms as physiologically relevant alternatives to conventional 2D and animal models for diabetes research. The central conclusion is that 3D models, such as organoids and organ-on-chip systems, improve the study of β-cell biology and drug discovery by better replicating human tissue microenvironments.
This is a narrative review article that synthesizes the current state and benefits of three-dimensional (3D) culture platforms for diabetes research, focusing on modeling pancreatic β-cells. The review argues that 3D models offer advantages by replicating tissue microenvironments, enhancing β-cell morphology, functionality, and intercellular crosstalk, which improves translational value for drug discovery. Central conclusions are that 3D models can reduce dependency on animal models and address limitations of 2D systems in predicting human responses. The authors note that while promising, 3D systems have limitations in complexity and require further development before widespread adoption.
