SEARCHNARRATIVE_REVIEWresearch methods, biomedical research

narrative_review·research methods, biomedical research, preclinical research, clinical trial, systematic review·PMC10448345

Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast

Photoacoustics · 7 authors, 6 centres

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The review covers PA imaging's principles, its integration with ultrasound, and its potential for imaging endogenous biomarkers such as hemoglobin, melanin, lipid, collagen, and water at clinically relevant depths. The review concludes that PA imaging of endogenous contrast has a promising path for clinical adoption due to its advantages, though it does not report original data or specific patient outcomes.

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narrative_review

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research methods

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ORIGINAL PAPER

PMC10448345

Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast

Photoacoustics

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ABSTRACT

Abstract In the past decade, photoacoustic (PA) imaging has attracted a great deal of popularity as an emergent diagnostic technology owing to its successful demonstration in both preclinical and clinical arenas by various academic and industrial research groups. Such steady growth of PA imaging can mainly be attributed to its salient features, including being non-ionizing, cost-effective, easily deployable, and having sufficient axial, lateral, and temporal resolutions for resolving various tissue characteristics and assessing the therapeutic efficacy. In addition, PA imaging can easily be integrated with the ultrasound imaging systems, the combination of which confers the ability to co-register and cross-reference various features in the structural, functional, and molecular imaging regimes. PA imaging relies on either an endogenous source of contrast (e.g., hemoglobin) or those of an exogenous nature such as nano-sized tunable optical absorbers or dyes that may boost imaging contrast beyond that provided by the endogenous sources. In this review, we discuss the applications of PA imaging with endogenous contrast as they pertain to clinically relevant niches, including tissue characterization, cancer diagnostics/therapies (termed as theranostics), cardiovascular applications, and surgical applications. We believe that PA imaging’s role as a facile indicator of several disease-relevant states will continue to expand and evolve as it is adopted by an increasing number of research laboratories and clinics worldwide. Keywords: Photoacoustics, Ultrasound, Spectroscopy, Diagnostics, Clinical, Endogenous, Image-guided, Interventions, Theranostics

CITATION EXPORT

Samuel John, Scott Hester, Maryam Basij et al.. Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast. Photoacoustics. (2023). https://doi.org/10.1016/j.pacs.2023.100533

AUTHORS

7 · 6 CENTRES

Samuel John, Scott Hester, Maryam Basij, Avijit Paul, Marvin Xavierselvan, Mohammad Mehrmohammadi, Srivalleesha Mallidi

aDepartment of Biomedical Engineering, Wayne State University, Detroit, MI, USA
bDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA
cDepartment of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, USA
dDepartment of Biomedical Engineering, University of Rochester, Rochester, NY, USA
eWilmot Cancer Institute, Rochester, NY, USA
fWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA