Nicotinamide Riboside and Phycocyanin Oligopeptides Affect Stress Susceptibility in Chronic Corticosterone-Exposed Rats
Antioxidants · 9 authors, 4 centres
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Combining NR with low-dose PC was more effective than NR with high-dose PC, suggesting a hormetic dose interaction.
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This preclinical study investigated whether NR and PC oligopeptide supplementation could attenuate chronic corticosterone (CORT)-induced oxidative stress, hepatic inflammation, and telomere shelterin protein disruption in rats. Chronic CORT exposure elevated hepatic MDA and serum corticosterone while suppressing antioxidant enzyme activities (SOD, CAT, GSH-Px) and increasing pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). NR and PC supplementation restored hepatic NAD+, NAM, and NADPH levels and modulated SIRT3 and NAMPT pathways. The combination of NR with low-dose PC was more effective than NR with high-dose PC for protecting telomere shelterin proteins and NAD+ metabolism, suggesting a hormetic interaction at high antioxidant doses. The authors note limitations including an inability to measure liver mTOR levels and uncertainty about why PC oligopeptides did not stimulate SIRT1.
