Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

The Journal of Biological Chemistry · 1 author, 1 centre

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TL;DR

This is a personal reflection article tracing the author's career, which has focused on cytochrome P450 enzyme research and its applications in fields like drug metabolism and toxicology. The central result is a narrative of his professional journey, not a scientific study.

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Peter Guengerich outlines his 98-semester career as a faculty member at Vanderbilt University, focusing on his research with cytochrome P450 enzymes. The author describes his family background, training, funding history, and service on the Journal of Biological Chemistry editorial board. The text details collaborative work, such as developing a mass spectrometry approach for analyzing DNA polymerase errors using the Dpo4 enzyme, which resulted in a JBC cover publication. The narrative includes personal anecdotes, career milestones like receiving awards and honorary degrees, and reflections on changes in NIH funding priorities and scientific publishing. The implications are primarily personal and professional, illustrating the scope and impact of long-term basic research in biochemistry.

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narrative_review

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biomedical research

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ORIGINAL PAPER

PMC10847173

Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?

The Journal of Biological Chemistry

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ABSTRACT

This Reflection article begins with my family background and traces my career through elementary and high school, followed by time at the University of Illinois, Vanderbilt University, the University of Michigan, and then for 98 semesters as a Vanderbilt University faculty member. My research career has dealt with aspects of cytochrome P450 enzymes, and the basic biochemistry has had applications in fields as diverse as drug metabolism, toxicology, medicinal chemistry, pharmacogenetics, biological engineering, and bioremediation. I am grateful for the opportunity to work with the Journal of Biological Chemistry not only as an author but also for 34 years as an Editorial Board Member, Associate Editor, Deputy Editor, and interim Editor-in-Chief. Thanks are extended to my family and my mentors, particularly Profs. Harry Broquist and Minor J. Coon, and the more than 170 people who have trained with me. I have never lost the enthusiasm for research that I learned in the summer of 1968 with Harry Broquist, and I have tried to instill this in the many trainees I have worked with. A sentence I use on closing slides is “It’s not just a laboratory—it’s a fraternity.”

CITATION EXPORT

F. Peter Guengerich. Ninety-eight semesters of cytochrome P450 enzymes and related topics—What have I taught and learned?. The Journal of Biological Chemistry. (2024). https://doi.org/10.1016/j.jbc.2024.105625

AUTHORS

1 · 1 CENTRES

F. Peter Guengerich

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA