“
TL;DR
No clear evidence of elevated neuropathy risk was found in the high-risk group, though parasympathetic neuropathy was more prevalent and HbA1c within the normal range was independently associated with it.
Frontiers in Endocrinology · 7 authors, 1 centre
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
No clear evidence of elevated neuropathy risk was found in the high-risk group, though parasympathetic neuropathy was more prevalent and HbA1c within the normal range was independently associated with it.
Cardiac autonomic function was assessed by standard Ewing tests and peripheral sensory neuropathy by Neurometer and Q-sense. Sensory nerve dysfunction was of low prevalence in high-risk patients and absent in controls, with thresholds remaining within normal reference ranges. In multiple logistic regression, HbA1c was independently associated with parasympathetic neuropathy (OR 5.9, p<0.041). The small sample size limits adjustment for confounders and subgroup analyses, and the cross-sectional design precludes causal conclusions. These findings suggest that increased diabetes risk without manifest glucose metabolism disorder does not clearly elevate neuropathy prevalence, though further prospective investigation is warranted.