SEARCHNARRATIVE_REVIEWneurology, nutrition

narrative_review·neurology, nutrition, clinical nutrition, preclinical research, systematic review·PMC10052985

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

Nutrients · 9 authors, 6 centres

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TL;DR

The review found that ginger, hesperidin, menthol, vitamin C, diaphragmatic breathing, and pleasant music may reduce motion sickness symptoms while avoiding medication side effects.

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This narrative review synthesized literature on pharmacological, nutritional, and behavioral interventions for motion sickness (MS) caused by sensory conflict between vestibular and visual systems. The review covered medications including scopolamine, antihistamines (cyclizine, dimenhydrinate, meclizine), and cinnarizine, noting that scopolamine at 0.6 mg delayed MS onset by 147% but doubling the dose increased side effects without added benefit. Behavioral interventions including diaphragmatic breathing, favorite music, fresh air, and pleasant odors activated the parasympathetic nervous system to reduce symptoms. High-fat meals were associated with worsened MS. Limitations include inconsistent ginger dosing across trials, conflicting results regarding protein intake, and varying study designs.

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narrative_review

SPECIALTY

neurology

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ORIGINAL PAPER

PMC10052985

Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review

Nutrients

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ABSTRACT

Abstract The mismatch in signals perceived by the vestibular and visual systems to the brain, also referred to as motion sickness syndrome, has been diagnosed as a challenging condition with no clear mechanism. Motion sickness causes undesirable symptoms during travel and in virtual environments that affect people negatively. Treatments are directed toward reducing conflicting sensory inputs, accelerating the process of adaptation, and controlling nausea and vomiting. The long-term use of current medications is often hindered by their various side effects. Hence, this review aims to identify non-pharmacological strategies that can be employed to reduce or prevent motion sickness in both real and virtual environments. Research suggests that activation of the parasympathetic nervous system using pleasant music and diaphragmatic breathing can help alleviate symptoms of motion sickness. Certain micronutrients such as hesperidin, menthol, vitamin C, and gingerol were shown to have a positive impact on alleviating motion sickness. However, the effects of macronutrients are more complex and can be influenced by factors such as the food matrix and composition. Herbal dietary formulations such as Tianxian and Tamzin were shown to be as effective as medications. Therefore, nutritional interventions along with behavioral countermeasures could be considered as inexpensive and simple approaches to mitigate motion sickness. Finally, we discussed possible mechanisms underlying these interventions, the most significant limitations, research gaps, and future research directions for motion sickness. Keywords: motion sickness, treatments, nutrition artificial intelligence

CITATION EXPORT

Ghazal Rahimzadeh, Abdullatif Tay, Nikolaj Travica et al.. Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review. Nutrients. (2023). https://doi.org/10.3390/nu15061320

AUTHORS

9 · 6 CENTRES

Ghazal Rahimzadeh, Abdullatif Tay, Nikolaj Travica, Kathleen Lacy, Shady Mohamed, Darius Nahavandi, Paweł Pławiak, Mohammadreza Chalak Qazani, Houshyar Asadi

1Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Geelong, VIC 3216, Australia
2PepsiCo Inc., Food Safety and Global Process Authority, 433 W Van Buren St., Chicago, IL 60607, USA
3Food & Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, Australia
4Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Geelong, VIC 3220, Australia
5Department of Computer Science, Faculty of Computer Science and Telecommunications, Cracow University of Technology, Warszawska 24, 31-155 Krakow, Poland
6Institute of Theoretical and Applied Informatics, Polish Academy of Sciences, Bałtycka 5, 44-100 Gliwice, Poland

Ghazal Rahimzadeh, Abdullatif Tay, Nikolaj Travica et al.. Nutritional and Behavioral Countermeasures as Medication Approaches to Relieve Motion Sickness: A Comprehensive Review. Nutrients. (2023). https://doi.org/10.3390/nu15061320