“
TL;DR
This retrospective cohort study of 888 patients undergoing liver resection found no significant difference in post-hepatectomy liver failure or major complications between normal weight, overweight, and obese patients.
Hepatobiliary Surgery and Nutrition · 9 authors, 3 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This retrospective cohort study of 888 patients undergoing liver resection found no significant difference in post-hepatectomy liver failure or major complications between normal weight, overweight, and obese patients.
This retrospective single-center cohort study analyzed 888 adult patients who underwent elective liver resection between 2004 and 2017, stratifying them into normal weight, overweight, and obese groups based on BMI. The primary aim was to assess the influence of BMI and nonalcoholic steatohepatitis (NASH) on post-hepatectomy liver failure (PHLF) and morbidity. Post-hepatectomy liver failure occurred in 16.3% of normal weight, 15.3% of overweight, and 11.4% of obese patients (P=0.32), with no significant association between weight group and postoperative complications (P=0.45). At multivariable analysis, only major liver resection was a significant predictor for PHLF (OR: 2.7, 95% CI: 1.83–4.04; P<0.001). Obesity was significantly associated with NASH and liver fibrosis, but these were not associated with PHLF or morbidity. Limitations include the retrospective design and use of BMI, which does not capture body composition. The findings suggest that liver resections can be safely performed in obese patients with modern techniques.