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TL;DR
Treatment with oleocanthal (10 mg/kg) modulated these metabolic and behavioral parameters toward wild-type values, with a more pronounced effect in older 5xFAD mice.
Molecules · 5 authors, 2 centres
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Treatment with oleocanthal (10 mg/kg) modulated these metabolic and behavioral parameters toward wild-type values, with a more pronounced effect in older 5xFAD mice.
This preclinical study used Promethion metabolic and behavioral phenotyping cages to assess age- and pathology-related changes in wild-type and 5xFAD mice at 4 and 9 months of age. 5xFAD-9m mice exhibited lower body weight than age-matched wild-type mice despite equivalent food intake, along with increased dehydration rate, hyperventilation, activity, movement, and reduced sleep. Wild-type mice showed decreased activity and metabolism with aging, whereas 5xFAD mice showed increased activity and metabolism, suggesting amyloid-beta-related anxiety-like behavior. A positive correlation between brain amyloid-beta and IgG extravasation (a marker of blood-brain barrier breakdown) was observed, along with a negative correlation between total sleep hours and IgG extravasation. Oleocanthal treatment at 10 mg/kg modulated metabolic and behavioral parameters toward wild-type values, with more prominent effects in older 5xFAD mice. Limitations include the use of only male mice, lack of confirmation with conventional anxiety tasks such as the open field test, and the need for additional studies to confirm correlation findings.