One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States

Journal of Health Economics and Outcomes Research · 6 authors, 1 centre

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The paper reports on one-year prevalence, comorbidities, and cost of hospitalizations for alpha-1 antitrypsin deficiency among COPD patients in the United States.

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The title indicates the study addresses one-year prevalence, comorbidities, and cost of hospitalizations for alpha-1 antitrypsin deficiency among patients with chronic obstructive pulmonary disease in the United States. Abstract keywords list hospitalization, COPD, chronic obstructive pulmonary disease, AATD, and alpha-1 antitrypsin deficiency, but no quantitative results, sample size, follow-up duration, statistical analyses, or stated limitations are reported in the supplied source. Because no outcome data were provided, the detailed narrative cannot describe specific prevalence estimates, comorbidity patterns, cost figures, or design features beyond what is implied by the title.

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other

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pulmonology

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AI pipeline

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ORIGINAL PAPER

PMC10471378

One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States

Journal of Health Economics and Outcomes Research

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ABSTRACT

Abstract Objectives: Little is known about severe chronic obstructive pulmonary disease (COPD) exacerbations among patients with Alpha-1 Antitrypsin Deficiency (AATD). We assessed inpatients with AATD and COPD among a sample of COPD inpatients to ascertain demographic, clinical and economic differences in the course of disease and treatment. Methods: Using data from the 2009 Nationwide Inpatient Sample (NIS), we identified COPD (ICD-9-CM: 491.xx, 492.xx, or 496.xx) patients with AATD (273.4). We compared patient demographics and healthcare outcomes (eg, length of stay, inpatient death, type and number of procedures, and cost of care) between COPD patients with and without alpha-1 antitrypsin deficiency. Frequencies and percentages for patient demographics were compared using bivariate statistics (eg, chi-square test). Recognizing the non-parametric nature of length of stay and cost, we calculated median values and interquartile ranges for these variables for each group of patients. Finally, the risk of inpatient death was estimated using logistic regression. Results: Of 840 242 patients with COPD (10.8% of the NIS sample population), 0.08% (684) had a primary or secondary diagnosis code for AATD. COPD+AATD were younger (56 vs 70, p<0.0001) and as a result, less likely to be covered by Medicare (44% vs 62%, p<0.0001). AATD patients were also more likely to have comorbid non-alcoholic liver disease (7% vs 2%, p<0.0001), depression (17% vs 13%, p=0.0328), and pulmonary circulation disorders (7% vs 4%, p=0.0299). Patients with AATD had a 14% longer length of stay (IRR = 1.14, 95% CI 1.07, 1.21) and a mean cost of $1487 (p=0.0251) more than COPD inpatients without AATD. Conclusions: AATD is associated with increased mean length of stay and cost, as well as higher frequency of comorbid non-alcoholic liver disease, depression, and pulmonary circulation disorders. Future research should assess other differences between AATD and the general COPD population such as natural history of disease, treatment responsiveness and disease progression. Keywords: hospitalization, copd, chronic obstructive pulmonary disease, aatd, alpha-1 antitrypsin deficiency

CITATION EXPORT

Christopher M Blanchette, Emily Zacherle, Joshua M Noone et al.. One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States. Journal of Health Economics and Outcomes Research. (2017). https://doi.org/10.36469/9799

AUTHORS

6 · 1 CENTRES

Christopher M Blanchette, Emily Zacherle, Joshua M Noone, Bryce A Van Doren, Debosree Roy, Reuben Howden

1University of North Carolina, Charlotte NC, USA