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TL;DR
The authors describe how COVID-19-associated immunosuppression — including declines in CD4+ and CD8+ T cells, elevated ferritin, endothelial damage, and broad-spectrum antibiotic use — predisposes patients to invasive fungal infections.
Avicenna Journal of Medicine · 7 authors, 5 centres
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The authors describe how COVID-19-associated immunosuppression — including declines in CD4+ and CD8+ T cells, elevated ferritin, endothelial damage, and broad-spectrum antibiotic use — predisposes patients to invasive fungal infections.
The authors describe how COVID-19-associated immunosuppression — including declines in CD4+ and CD8+ T cells, elevated ferritin, endothelial damage, and broad-spectrum antibiotic use — predisposes patients to invasive fungal infections. Diagnostic approaches discussed include histopathology, culture, (1,3)-β-D-glucan, galactomannan, PCR, and MALDI-TOF. First-line therapies differ significantly across fungal species. The review recommends considering risk factors, diagnostic procedure trade-offs, and clinical context for management.