Scientific Reports · 15 authors, 5 centres
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This retrospective cross-sectional study of 427 patients determined that a DEQS cutoff of 15.0 points optimally detects dry eye disease when combined with tear film breakup time ≤5 s. DEQS cutoffs of 15.0, 20.0, and 26.8 points were proposed for classifying DED severity as mild, moderate, and severe.
DED was diagnosed per 2016 Asia Dry Eye Society criteria combining J-OSDI ≥13 points and TFBUT ≤5 s. ROC analysis identified an optimal DEQS cutoff of 15.0 points for DED diagnosis (AUC 0.915, sensitivity 83.5%, specificity 87.0%). Additional DEQS cutoffs of 15.0, 20.0, and 26.8 points were proposed for mild, moderate, and severe DED symptom severity classification, corresponding to J-OSDI thresholds. Limitations include single-center Japanese data, an older and predominantly female sample, and potential selection bias limiting generalizability to broader populations.
