Outer nuclear layer recovery as a predictor of visual prognosis in type 1 choroidal neovascularization of neovascular age-related macular degeneration

Scientific Reports · 5 authors, 2 centres

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TL;DR

OCT biomarkers including foveal outer nuclear layer (ONL) thickness, subretinal fluid height, choroidal thickness, and ellipsoid zone integrity were assessed at baseline, after three loading doses, and at 1-year follow-up.

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222 CHARS

STUDY TYPE

case-control

SPECIALTY

ophthalmology

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ORIGINAL PAPER

PMC10050211

Outer nuclear layer recovery as a predictor of visual prognosis in type 1 choroidal neovascularization of neovascular age-related macular degeneration

Scientific Reports

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ABSTRACT

Abstract To investigate the changes in outer nuclear layer (ONL) thickness during anti-vascular endothelial growth factor (VEGF) treatment in type 1 choroidal neovascularization (CNV) and its impact on vision. Type 1 CNV eyes (n = 94) were retrospectively compared to normal control eyes (n = 35). Along with best-corrected visual acuity (BCVA), the location of CNV, foveal ONL thickness, and subretinal fluid height were measured using optical coherence tomography (OCT) and analyzed. Visual outcome and OCT biomarkers were compared. As a result, the CNV group had thinner foveal ONL and worse BCVA compared to the control group. ONL thickness recovered partially along with visual improvement following 3 monthly initial loading doses of aflibercept injections, and it correlated with the final BCVA during the 1-year follow-up. Eyes achieved foveal ONL recovery over + 10 µm had lower subfoveal CNV (45.5%) and showed better visual outcomes than eyes with stationary ONL or suboptimal ONL recovery (76.0%, p = 0.012). In conclusion, type 1 CNV eyes that recovered foveal ONL thickness at initial loading of anti-VEGF demonstrated good final visual outcome during the 1-year follow-up. Monitoring the foveal ONL thickness during early anti-VEGF treatment can give information about the visual outcomes in type 1 CNV. Subject terms: Eye manifestations, Prognostic markers

CITATION EXPORT

Seungheon Lee, Kyung Tae Kim, Dong Yoon Kim et al.. Outer nuclear layer recovery as a predictor of visual prognosis in type 1 choroidal neovascularization of neovascular age-related macular degeneration. Scientific Reports. (2023). https://doi.org/10.1038/s41598-023-32184-5

AUTHORS

5 · 2 CENTRES

Seungheon Lee, Kyung Tae Kim, Dong Yoon Kim, Ju Byung Chae, Eoi Jong Seo

1Department of Ophthalmology, College of Medicine, Chungbuk National University Hospital, Chungbuk National University, 776, Sunhwan-1-Ro, Seowon-Gu, Cheongju, 28644 Korea
2Seoul Top Eye Center, Cheongju, Korea