SEARCHNARRATIVE_REVIEWinternal medicine, nutrition

narrative_review·internal medicine, nutrition, clinical nutrition, vitamins·PMC10058027

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

International Journal of Molecular Sciences · 2 authors, 2 centres

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TL;DR

The authors synthesize in vitro, in vivo animal, and primarily human clinical data published between January 2018 and January 2023.

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The authors synthesize in vitro, in vivo animal, and primarily human clinical data published between January 2018 and January 2023. The review notes a rethinking of plant-derived supplements as treatment options for mild-to-moderate lower urinary tract symptoms (LUTS) associated with BPH. Limitations include the narrative, non-systematic nature of the review, which synthesizes a broad range of evidence levels. The implications suggest these supplements hold promise, but further research is needed to determine their efficacy and role.

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narrative_review

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internal medicine

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100% · A

ORIGINAL PAPER

PMC10058027

Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome

International Journal of Molecular Sciences

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ABSTRACT

Benign prostatic hyperplasia (BPH) is an age-related disorder, which is one of the most prevalent and costly benign neoplasms in men with over 94 million cases worldwide. Starting before or around 50 years of age, there is a linear increase in prostate volume and BPH symptoms, which are influenced by changes in hormonal, inflammatory, growth factors, cell receptor signaling, diet, physical activity, and the microbiome of the prostate that leads to cellular proliferation. While current pharmaceutical or surgical treatments are currently available, each treatment has serious side effects. This dilemma has motived men to seek treatment without negative side effects from medicinal plants such as botanicals, phytochemicals, and vitamins that have established safety records. This narrative overview focuses on several botanicals, phytochemicals and vitamins that are widely used in the treatment of BPH and emphasizes how, in some cases, combinations of these natural ingredients may provide better BPH symptom relief compared to utilization of a single medicinal plant product (monotherapy). Finally, this overview highlights in vitro, in vivo animal studies and mainly clinical data of journal reports published in the past 5 years from January 2018 to January 2023 on BPH and nutraceuticals. Notably, there is an evolving perspective or rethinking of the role that medicinal phytochemicals and natural vitamins usage play; that is, they may hold promise or are likely to alleviate BPH symptoms.

CITATION EXPORT

Kendal L. Stewart, Edwin D. Lephart. Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms24065486

AUTHORS

2 · 2 CENTRES

Kendal L. Stewart, Edwin D. Lephart

1Neurosensory Centers of America, Inc., Austin, TX 78738, USA
2Department of Cell Biology, Physiology and The Neuroscience Center, College of Life Sciences, Brigham Young University, Provo, UT 84602, USA

EDITOR / REVIEWER

Sonia A.O. Santos, Armando J. D. Silvestre, Raphael Grougnet, Vessela Balabanova