SEARCHNARRATIVE_REVIEWophthalmology, preclinical research

narrative_review·ophthalmology, preclinical research, biomedical research·PMC10607833

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

International Journal of Molecular Sciences · 3 authors, 1 centre

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TL;DR

The review discusses FDA-approved nano-based ophthalmic formulations, including Cequa® (cyclosporine A 0.09% nanomicellar solution) for dry eye disease.

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The review discusses FDA-approved nano-based ophthalmic formulations, including Cequa® (cyclosporine A 0.09% nanomicellar solution) for dry eye disease. The review does not report original experimental data.

STUDY TYPE

narrative_review

SPECIALTY

ophthalmology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10607833

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

International Journal of Molecular Sciences

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ABSTRACT

Abstract Ocular diseases profoundly impact patients’ vision and overall quality of life globally. However, effective ocular drug delivery presents formidable challenges within clinical pharmacology and biomaterial science, primarily due to the intricate anatomical and physiological barriers unique to the eye. In this comprehensive review, we aim to shed light on the anatomical and physiological features of the eye, emphasizing the natural barriers it presents to drug administration. Our goal is to provide a thorough overview of various characteristics inherent to each nano-based drug delivery system. These encompass nanomicelles, nanoparticles, nanosuspensions, nanoemulsions, microemulsions, nanofibers, dendrimers, liposomes, niosomes, nanowafers, contact lenses, hydrogels, microneedles, and innovative gene therapy approaches employing nano-based ocular delivery techniques. We delve into the biology and methodology of these systems, introducing their clinical applications over the past decade. Furthermore, we discuss the advantages and challenges illuminated by recent studies. While nano-based drug delivery systems for ophthalmic formulations are gaining increasing attention, further research is imperative to address potential safety and toxicity concerns. Keywords: ocular barriers, ocular drug delivery, nanocarriers, nano-based drug delivery system, ocular bioavailability

CITATION EXPORT

Li-Ching Liu, Yi-Hao Chen, Da-Wen Lu. Overview of Recent Advances in Nano-Based Ocular Drug Delivery. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms242015352

AUTHORS

3 · 1 CENTRES

Li-Ching Liu, Yi-Hao Chen, Da-Wen Lu

1Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan; [email protected] (L.-C.L.); [email protected] (Y.-H.C.)