HemaSphere · 11 authors, 4 centres
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This cross-sectional study found that gut microbial diversity and the abundance of key butyrate-producing bacteria remained significantly lower in long-term survivors of allogeneic hematopoietic stem cell transplantation compared to healthy controls, with no recovery observed up to over 10 years post-transplant.
The study analyzed the gut microbiota of 59 long-term survivors (median 6.4 years post-transplant) of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and compared them to 59 age- and sex-matched healthy controls using alpha (Shannon index) and beta diversities. Long-term survivors exhibited significantly lower gut microbial diversity than healthy controls, characterized by a reduced abundance of butyrate-producing bacteria like Coprococcus and Faecalibacterium. Factors like age, sex, antibiotic use, and probiotics at the time of sampling did not significantly affect the observed reduced diversity.
