Sports Medicine - Open · 8 authors, 6 centres
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This individual participant data meta-analysis found that a single prolonged, continuous running bout caused a transient increase in the bone formation marker P1NP that was not sustained, and did not cause a change in the bone resorption marker β-CTX-1 compared to typical circadian variation in young healthy adult males.
The central result was that while P1NP levels increased during and immediately after running, returning to baseline within 1 hour, this change was likely a transient biological artefact rather than true bone formation. There was no evidence of a running-induced change in β-CTX-1 levels during or up to four days post-exercise; small observed decreases were similar to those seen in non-exercise control data and attributed to circadian rhythm. The analysis concluded that this type of running bout did not elicit bone responses as determined by these systemic markers. A key limitation was that control data were predominantly from different participants, and factors like plasma volume shifts were not accounted for in the included studies.
