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other·oncology, biomedical research, antioxidants, preclinical research·PMC10255713

Palm Fruit ( Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage

Nutrients · 6 authors, 7 centres

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TL;DR

Researchers found that PFPE inhibited free radical activities and protected against DNA and protein damage.

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Researchers found that PFPE inhibited free radical activities and protected against DNA and protein damage. The extract was observed to up-regulate pro-apoptotic genes p53 and Caspase-9 while down-regulating oncogenes Bcl-2 and p21. Limitations include the preclinical, in vitro nature of the research, which does not establish efficacy or safety in humans.

STUDY TYPE

other

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10255713

Palm Fruit ( Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage

Nutrients

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ABSTRACT

Abstract Palm fruit pollen extract (PFPE) is a natural source of bioactive polyphenols. The primary aim of the study was to determine the antioxidant, antimicrobial, anticancer, enzyme inhibition, bovine serum albumin (BSA), and DNA-protective properties of PFPE and identify and quantify the phenolic compounds present in PFPE. The results demonstrated that PFPE exhibited potent antioxidant activity in various radical-scavenging assays, including (2,2-diphenyl-1-picrylhydrazyl) (DPPH • ), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS • ), nitric oxide (NO), ferric-reducing/antioxidant power (FRAP), and total antioxidant capacity (TAC). PFPE also displayed antimicrobial activity against several pathogenic bacteria. Similarly, PFPE reduced acetylcholinesterase, tyrosinase, and α-amylase activities. PFPE has been proven to have an anticancer effect against colon carcinoma (Caco-2), hepatoma (HepG-2), and breast carcinoma (MDA) cancer cells. Apoptosis occurred in PFPE-treated cells in a dose-dependent manner, and cell cycle arrest was observed. Furthermore, in breast cancer cells, PFPE down-regulated Bcl-2 and p21 and up-regulated p53 and Caspase-9. These results show that PFPE constitutes a potential source of polyphenols for pharmaceutical, nutraceutical, and functional food applications. Keywords: palm fruit pollen, antibacterial activity, antioxidant capacity, DNA-protective, human pathogens, apoptosis

CITATION EXPORT

Hosam M Habib, Esmail M El-Fakharany, Hamada El-Gendi et al.. Palm Fruit (Phoenix dactylifera L.) Pollen Extract Inhibits Cancer Cell and Enzyme Activities and DNA and Protein Damage. Nutrients. (2023). https://doi.org/10.3390/nu15112614

AUTHORS

6 · 7 CENTRES

Hosam M Habib, Esmail M El-Fakharany, Hamada El-Gendi, Mohamed G El-Ziney, Ahmed F El-Yazbi, Wissam H Ibrahim

1Research & Innovation Hub, Alamein International University (AIU), Alamein City 5060310, Egypt; [email protected] (H.M.H.); [email protected] (A.F.E.-Y.)
2Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA City), New Borg El Arab, Alexandria P.O. Box 21934, Egypt; [email protected]
3Bioprocess Development Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA City), New Borg El Arab, Alexandria P.O. Box 21934, Egypt; [email protected]
4Dairy Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria P.O. Box 21545, Egypt; [email protected]
5Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt
6Faculty of Pharmacy, Alamein International University (AIU), Alamein City 5060310, Egypt
7Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates