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cohort·epidemiology, pediatrics, public health, nutrition, endocrinology·PMC10438875

Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study

The Journal of Clinical Endocrinology and Metabolism · 8 authors, 16 centres

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TL;DR

This prospective cohort study examined body composition in 240 UK parent-child trios at three childhood ages.

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This prospective cohort study from the Southampton Women's Survey analyzed 240 mother-father-offspring trios. Offspring body composition was assessed via DXA and anthropometry at ages 4, 6-7, and 8-9 years. Parental body composition was assessed when offspring were 8-9 years old. The primary analysis used linear regression to examine mother-offspring and father-offspring associations, adjusting for the other parent. The central result was a strong positive association between mothers and daughters for BMI and fat mass at ages 6-7 and 8-9, with weaker associations for lean mass. The authors discuss potential mechanisms including intrauterine programming, shared postnatal environment, and biological sex differences. The findings suggest a need for focused early prevention for daughters of mothers with excess adiposity.

STUDY TYPE

cohort

SPECIALTY

epidemiology

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100% · A

ORIGINAL PAPER

PMC10438875

Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study

The Journal of Clinical Endocrinology and Metabolism

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ABSTRACT

Abstract Context Children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent. Objective To examine differential mother-offspring and father-offspring associations in body composition in early childhood. Methods A total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort (Southampton Women's Survey) were included for anthropometry and dual-energy x-ray absorptiometry assessment of whole-body-less-head body composition in the offspring at 3 different ages (4, 6-7, and 8-9 years) and in the mother and father at the 8- to 9-year offspring visit. Associations were assessed using linear regression adjusting for the other parent. Results Positive associations between mother-daughter body mass index (BMI) and fat mass were observed at ages 6 to 7 (BMI: β = .29 SD/SD, 95% CI = .10, .48; fat mass β = .27 SD/SD, 95% CI = .05, .48) and 8 to 9 years (BMI: β = .33 SD/SD, 95% CI = .13, .54; fat mass β = .31 SD/SD, 95% CI = .12, .49), with similar associations at age 4 years but bounding the 95% CI. The mother-son, father-son, and father-daughter associations for BMI and fat mass were weaker at each of the ages studied. Conclusion A strong association between the fat mass of mothers and their daughters but not their sons was observed. In contrast, father-offspring body composition associations were not evident. The dimorphic parent-offspring effects suggest particular attention should be given to early prevention of unfavorable body composition in girls born to mothers with excess adiposity. Keywords: adiposity, obesity, developmental programming

CITATION EXPORT

Rebecca J Moon, Stefania D’Angelo, Christopher R Holroyd et al.. Parent-Offspring Associations in Body Composition: Findings From the Southampton Women's Survey Prospective Cohort Study. The Journal of Clinical Endocrinology and Metabolism. (2023). https://doi.org/10.1210/clinem/dgad128

AUTHORS

8 · 16 CENTRES

Rebecca J Moon, Stefania D’Angelo, Christopher R Holroyd, Sarah R Crozier, Keith M Godfrey, Justin H Davies, Cyrus Cooper, Nicholas C Harvey

1 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
2 Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
3 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
4 Department of Rheumatology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
5 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
6 NIHR Applied Research Collaboration Wessex, Southampton Science Park, Innovation Centre, Southampton, SO16 7NP, UK
7 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
8 Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
9 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
10 Paediatric Endocrinology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
11 Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK
12 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
13 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
14 NIHR Biomedical Research Centre, University of Oxford, Oxford OX4 2PG, UK
15 MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton SO16 6YD, UK
16 NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK