A 12-year-old boy developed cervicofacial necrotizing fasciitis secondary to second inferior molar pericoronitis, which progressed to the contralateral side and mediastinum within approximately 48 hours despite intravenous antibiotics. Management required repeated surgical debridement, prolonged intubation, and multidisciplinary care complicated by ventilation-assisted bronchopneumonia, aspiration pneumonia, and pressure ulcers.