Perioperative Enteral Immunonutrition Support for the Immune Function and Intestinal Mucosal Barrier in Gastric Cancer Patients Undergoing Gastrectomy: A Prospective Randomized Controlled Study

Nutrients · 6 authors, 1 centre

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Participants received either perioperative enteral immunonutrition or standard enteral nutrition.

Full summary

643 CHARS

Participants received either perioperative enteral immunonutrition or standard enteral nutrition. The primary outcome was postoperative complications, which were significantly lower in the immunonutrition group (p=0.039). The study found that immunonutrition significantly reduced serum markers of intestinal mucosal damage (diamine oxidase, D-lactic acid, and endotoxin) on both the 3rd and 7th postoperative days compared to standard nutrition. The study noted a significant moderate positive correlation between postoperative complications and endotoxin levels, suggesting the benefit may be linked to improved intestinal barrier integrity.

STUDY TYPE

RCT

SPECIALTY

surgery

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10647624

Perioperative Enteral Immunonutrition Support for the Immune Function and Intestinal Mucosal Barrier in Gastric Cancer Patients Undergoing Gastrectomy: A Prospective Randomized Controlled Study

Nutrients

READ THE FULL PAPER

ABSTRACT

Objective: The impact of perioperative immunonutrition on patients undergoing radical gastrectomy remains undetermined. This study aimed to assess the influence of enteral immunonutrition support on postoperative immune function and intestinal mucosal barrier function following radical gastrectomy, contrasting findings with a control group to furnish evidence for perioperative enteral nutrition support. Methods: In this prospective randomized trial, 65 patients who underwent radical gastrectomy between June 2022 and June 2023 were included. Participants were allocated to either the study group (receiving enteral immunonutrition) or the control group (not receiving enteral immunonutrition). We compared postoperative rehabilitation and complications between the groups, analyzed the intestinal mucosal barrier function markers on the 3rd and 7th postoperative days, and delved deeper into peripheral blood cell immunity, inflammation, and nutritional indicators. Results: The cohort consisted of 30 patients in the study group and 35 in the control group, with no significant differences in demographic attributes between the two groups. On the 3rd postoperative day, the diamine oxidase, D-lactic acid, and endotoxin levels in the study group were significantly lower than those in the control group ( p = 0.029, p = 0.044, and p = 0.010, respectively). By the 7th postoperative day, these levels continued to be significantly diminished in the study group ( p = 0.013, p = 0.033, and p = 0.004, respectively). The times to first flatus ( p = 0.012) and first bowel movement ( p = 0.012) were significantly shorter in the study group. Moreover, postoperative complications in the study group were fewer than in the control group ( p = 0.039). On the 7th postoperative day, the study group had lower peripheral white blood cell (WBC) levels ( p = 0.020) and neutrophil–lymphocyte ratios (NLR) ( p = 0.031), but displayed elevated albumin levels ( p = 0.006). One month post-surgery, the CD4+T and CD8+T counts were significantly greater in the study group ( p = 0.003 and p = 0.012, respectively). Correlation analyses indicated that NLR and complications were associated with endotoxin levels. Conclusion: Administering perioperative enteral immunonutrition enhances postoperative immune and intestinal mucosal barrier functions in patients undergoing radical gastrectomy. This effect leads to diminished inflammatory responses, a decreased rate of postoperative complications, and accelerated patient recovery.

CITATION EXPORT

Mingwei Ma, Zicheng Zheng, Ziyang Zeng et al.. Perioperative Enteral Immunonutrition Support for the Immune Function and Intestinal Mucosal Barrier in Gastric Cancer Patients Undergoing Gastrectomy: A Prospective Randomized Controlled Study. Nutrients. (2024). https://doi.org/10.3390/nu15214566

AUTHORS

6 · 1 CENTRES

Mingwei Ma, Zicheng Zheng, Ziyang Zeng, Jie Li, Xin Ye, Weiming Kang

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China; [email protected] (M.M.); [email protected] (Z.Z.); [email protected] (Z.Z.); [email protected] (J.L.); [email protected] (X.Y.)

EDITOR / REVIEWER

Edith Lahner, Jaime Uribarri, Camilla Fiorindi, Francesco Giudici