Scientific Reports · 12 authors, 5 centres
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In a prospective cohort of 18,714 French adults followed over a median of 8.05 years, person-centered cardiovascular health metrics showed high concordance with gold-standard measured metrics (weighted coefficient 0.87) and both were inversely associated with incident cardiovascular disease, though person-centered metrics yielded a stronger per-metric risk reduction estimate.
Person-centered biological metrics were defined by diagnoses, medication, or treatment for hypertension, type 2 diabetes, and hypercholesterolemia; measured biological metrics came from clinical examinations and blood analyses. Behavioral metrics were shared between both approaches. Weighted concordance between person-centered and measured CVH was 0.87. Over a median follow-up of 8.05 years, 749 CVD events occurred. Each additional ideal measured LS7 metric was associated with a 7% CVD risk reduction (HR 0.93), while each additional ideal person-centered LS7 metric was associated with a 13% risk reduction (HR 0.87). The authors attributed the stronger person-centered estimate to misclassification of biological metrics. Change analysis in a larger subsample showed that improvement in person-centered CVH was independently associated with CVD risk reduction. Limitations include a predominantly female, high-income French sample with a single baseline measurement of biological metrics, potential residual confounding, and absence of ethnicity data.
