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narrative_review·preclinical research, biomedical research, research methods·PMC10540072

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery

Frontiers in Bioengineering and Biotechnology · 6 authors, 3 centres

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TL;DR

The review discusses two mechanisms for pH-responsive drug delivery: ionizable group conformational changes and ionic interactions between polymer and drug.

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The review discusses two mechanisms for pH-responsive drug delivery: ionizable group conformational changes and ionic interactions between polymer and drug. The review synthesizes preclinical findings from multiple cited studies, such as chitosan hydrogels retaining in dog stomachs for over 48 hours and guar gum–alginate beads releasing more ibuprofen at pH 7.4 than at pH 1.2.

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narrative_review

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preclinical research

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AI pipeline

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ORIGINAL PAPER

PMC10540072

pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery

Frontiers in Bioengineering and Biotechnology

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ABSTRACT

Abstract Over the past several decades, there has been significant growth in the design and development of more efficient and advanced biomaterials based on non-cellulosic biological macromolecules. In this context, hydrogels based on stimuli-responsive non-cellulosic biological macromolecules have garnered significant attention because of their intrinsic physicochemical properties, biological characteristics, and sustainability. Due to their capacity to adapt to physiological pHs with rapid and reversible changes, several researchers have investigated pH-responsive-based non-cellulosic polymers from various materials. pH-responsive hydrogels release therapeutic substances in response to pH changes, providing tailored administration, fewer side effects, and improved treatment efficacy while reducing tissue damage. Because of these qualities, they have been shown to be useful in a wide variety of applications, including the administration of chemotherapeutic drugs, biological material, and natural components. The pH-sensitive biopolymers that are utilized most frequently include chitosan, alginate, hyaluronic acid, guar gum, and dextran. In this review article, the emphasis is placed on pH stimuli-responsive materials that are based on biological macromolecules for the purposes of drug administration. Keywords: non-cellulosic biological macromolecules, pH-sensitive polymer, hydrogel, drug delivery, formulation

CITATION EXPORT

Udaykumar Vegad, Megha Patel, Dignesh Khunt et al.. pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. Frontiers in Bioengineering and Biotechnology. (2023). https://doi.org/10.3389/fbioe.2023.1270364

AUTHORS

6 · 3 CENTRES

Udaykumar Vegad, Megha Patel, Dignesh Khunt, Ožbej Zupančič, Sanjay Chauhan, Amrit Paudel

1 Graduate School of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, India
2 Research Center Pharmaceutical Engineering GmbH (RCPE), Graz, Austria
3 Institute of Process and Particle Engineering, Graz University of Technology, Graz, Austria