SEARCHSYSTEMATIC_REVIEWsystematic review, clinical nutrition

systematic_review·systematic review, clinical nutrition, internal medicine, critical care, epidemiology·PMC10036242

Phase angle and COVID-19: A systematic review with meta-analysis

Reviews in Endocrine & Metabolic Disorders · 7 authors, 6 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

Lower PhA values were consistently associated with poorer clinical outcomes, including mortality and disease severity.

Full summary

534 CHARS

This PRISMA-guided systematic review with meta-analysis synthesized evidence from 8 studies on the prognostic value of phase angle (PhA) in COVID-19 patients. The review analyzed PhA measurements, hydration status, and lean soft tissue mass, finding that significantly lower PhA values were recorded in patients with poor outcomes, such as ICU admission and mortality, compared to those with better outcomes. For instance, a low PhA was an independent predictor for 90-day mortality (HR=3.912) and post-extubation dysphagia (OR=12.2).

STUDY TYPE

systematic_review

SPECIALTY

systematic review

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10036242

Phase angle and COVID-19: A systematic review with meta-analysis

Reviews in Endocrine & Metabolic Disorders

READ THE FULL PAPER

ABSTRACT

Abstract Phase angle (PhA) has been identified as a poor prognostic factor in patients with COVID-19. This study aimed to achieve a systematic review, where we discussed the potential role of PhA value as a prognostic marker of adverse clinical outcomes such as mortality and complication in hospitalized with SARS-CoV2 infection and established the strength of recommendations for use. A systematic literature review with meta-analysis was done in the main electronic databases from 2020 to January 2023. The selected articles had to investigate adverse consequences of the COVID-19 population and raw bioimpedance parameters such as PhA and published in peer-reviewed journals. GRADE tools regarded the quality of the methodology. The review protocol was registered in PROSPERO. Only eight studies, 483 studies, were eligible for the analysis. In general, differences in PhA were seen between the comparative study groups. Patients with a low PhA experienced poor outcomes. A low PhA was associated with a significantly increased mortality risk [RR: 2.44; 95% CI (1.20–4.99), p = 0.01; I2 = 79% (p = 0.0008)] and higher complications risk [OR: 3.47, 95% CI (1.16 – 10.37), p = 0.03; I2 = 82% (p = 0.004)] in COVID-19 patients. Our analysis showed four evidence-based recommendations on the prognostic value of PhA with two strong recommendations, one of moderate and another of low-moderate quality, for predicting mortality and complications, respectively. We recommend using PhA as a prognostic marker for mortality and complications in this population. Although the results are promising, future studies must identify the PhA cut-off to guide therapeutic decisions more precisely. Registration code in PROSPERO: CRD42023391044 Keywords: COVID-19, SARS-CoV2, Mortality, Phase angle, Vectorial bioimpedance, Bioelectrical impedance, Body composition, Length of stay, Sarcopenia, Malnutrition, Dysphagia

CITATION EXPORT

Isabel Cornejo-Pareja, Isabel M Vegas-Aguilar, Rocío Fernández-Jiménez et al.. Phase angle and COVID-19: A systematic review with meta-analysis. Reviews in Endocrine & Metabolic Disorders. (2023). https://doi.org/10.1007/s11154-023-09793-6

AUTHORS

7 · 6 CENTRES

Isabel Cornejo-Pareja, Isabel M Vegas-Aguilar, Rocío Fernández-Jiménez, Cristina García-García, Diego Bellido-Guerrero, Francisco Tinahones, Jose Manuel García-Almeida

1Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Malaga University, 29010 Malaga, Spain
2Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria University Hospital, 29010 Málaga, Spain
3Centro de Investigacion Biomedica en Red de la Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 29010 Malaga, Spain
4Málaga University, 29010 Málaga, Spain
5Department of Endocrinology and Nutrition, Complejo Hospitalario Universitario de Ferrol, Ferrol, La Coruña Spain
6Department of Endocrinology and Nutrition, Quironsalud Málaga Hospital, 29004 Málaga, Spain