PLOS ONE · 12 authors, 3 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This prospective study compared 61 women with early-stage breast cancer undergoing chemotherapy to 58 healthy controls, finding that chemotherapy worsened phase angle (PhA) and that PhA was positively correlated with antioxidant markers after treatment.
This prospective cohort study assessed the relationship between phase angle (PhA) and oxidative stress in 61 women with early-stage breast cancer undergoing chemotherapy compared to 58 healthy controls. Assessments included bioelectrical impedance, dietary recall, and blood samples at diagnosis (T0) and after one month of completing therapy (T1). Multiple linear regression analysis showed that at T1, PhA was significantly predicted by C-reactive protein, DPPH, malondialdehyde, total body water/extracellular water ratio, body mass index, and fat mass, explaining 58% of PhA variability (p<0.001). Limitations include the single-center design, potential lack of generalizability due to BIA device variability, and the absence of a specific PhA cutoff for oxidative stress. The findings suggest PhA may be a potential inexpensive tool to monitor oxidative stress in breast cancer patients.
