Molecules · 4 authors, 3 centres
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This preclinical animal study tested Egyptian *Sonchus oleraceus* leaves extract (SOE) on alloxan-induced diabetic rats to evaluate its anti-diabetic effects. SOE at doses of 200 and 300 mg/kg significantly improved blood glucose, lipid profiles, liver/kidney function, and pancreatic histology over 56 days compared to a diabetic control group.
This preclinical in vivo study evaluated the antidiabetic and antioxidant properties of an ethanolic extract from Egyptian *Sonchus oleraceus* leaves (SOE) in alloxan-induced diabetic Wister albino rats. Rats were grouped (n=7 per group) and treated for 56 days. Compared to the diabetic control, SOE at 200 and 300 mg/kg significantly decreased blood glucose, total lipid, total cholesterol, and LDL-cholesterol, while boosting HDL-cholesterol and improving liver and kidney function markers. Histological analysis showed the 300 mg/kg SOE treatment significantly improved pancreatic tissue structure. The findings suggest Egyptian SOE has potential as a natural antidiabetic agent without adverse effects on liver, kidney, or lipid profiles in this animal model.
