SEARCHCOHORTobstetrics and gynecology, pediatrics

cohort·obstetrics and gynecology, pediatrics, public health, epidemiology, endocrinology·PMC10439006

Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study

International Journal of Obesity (2005) · 5 authors, 23 centres

AI SUMMARY

FIDELITY 100%

POPULATIONPregnant women with a BMI ≥29 kg/m^2 and their offspring (213 mother-child pairs)

INTERVENTIONMaternal moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) measured repeatedly with accelerometers across pregnancy

COMPARISONComparisons based on mean levels and changes (slopes) in MVPA and ST

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This study analyzed 213 mother-child pairs from the DALI study, where mothers had a BMI ≥29 kg/m^2, to see if maternal physical activity and sedentary time during pregnancy were linked to newborn fat and cord blood markers.

Full summary

616 CHARS

This secondary analysis of the DALI study cohort used accelerometers to repeatedly measure moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) across pregnancy in 213 women with obesity. The central finding was a sex-specific association: higher mean MVPA and an increase in MVPA during pregnancy were associated with lower neonatal FM% in male offspring (−0.520% and −4.649%, respectively). No significant associations were found for birthweight or most other cord blood parameters. The results suggest maternal physical activity may influence neonatal adiposity, a predictor of childhood obesity.

PICO

PPOPULATION

Pregnant women with a BMI ≥29 kg/m^2 and their offspring (213 mother-child pairs)

IINTERVENTION

Maternal moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) measured repeatedly with accelerometers across pregnancy

OOUTCOME

Neonatal anthropometry (birthweight, fat mass percentage) and cord blood parameters (C-peptide, leptin, lipids)

STUDY TYPE

cohort

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10439006

Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study

International Journal of Obesity (2005)

READ THE FULL PAPER

ABSTRACT

Abstract Background/Objectives Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Subjects/Methods Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m 2 were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Results Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (−0.520%; 95% CI: −1.011%, −0.031% and −4.649%; −7.876%, −1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (−0.145 µg/l; −0.279 µg/l, −0.005 µg/l). No associations were found with birthweight or other cord blood parameters. Conclusions Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy. Subject terms: Paediatrics, Public health, Obesity, Epidemiology

CITATION EXPORT

Anna M Dieberger, Barbara Obermayer-Pietsch, Jürgen Harreiter et al.. Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study. International Journal of Obesity (2005). (2023). https://doi.org/10.1038/s41366-023-01347-9

AUTHORS

5 · 23 CENTRES

Anna M Dieberger, Barbara Obermayer-Pietsch, Jürgen Harreiter, Gernot Desoye, Mireille N M van Poppel

1Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
2Division of Endocrinology and Diabetology, Endocrinology Lab Platform, Department of Internal Medicine and Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
3Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
4Institute of Human Movement Science, Sport and Health, University of Graz, Graz, Austria
5Macarthur Clinical School, School of Medicine, Western Sydney University, Campbelltown, NSW Australia
6Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
7CIBER-BBN, ISCIII, Madrid, Spain
8Gender Institute Lapura, Gars am Kamp, Austria
9Department of Obstetrics and Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark
10Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
11Department of Endocrinology and Center for Pregnant Women with Diabetes,Rigshospitalet, Copenhagen, Denmark
12Department of Endocrinology and Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
13Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
14Clinical Research Facility and College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland
15Università Degli Studi di Padova, Padua, Italy
16Azienda Ospedaliero Universitaria Pisa, Pisa, Italy
17Department of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
18Amsterdam Public Health Research Institute, Health Behaviors & Chronic Diseases, Amsterdam, The Netherlands
19Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
20Medical Faculty I, Poznan University of Medical Sciences, Poznan, Poland
21Lawson Health Research Institute, London, ON Canada
22KU Leuven Department of Development and Regeneration: Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium
23Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands