Nature Communications · 12 authors, 14 centres
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In a nested case-control study within three US health professional cohorts and a cross-sectional analysis in the UK Biobank, higher levels of diglycerides and triglycerides were adversely associated with primary open-angle glaucoma risk across all four cohorts.
This study evaluated plasma metabolites in relation to primary open-angle glaucoma across four cohorts. A nested case-control study of 599 cases and 599 matched controls within the Nurses’ Health Studies and Health Professionals’ Follow-Up Study measured 369 metabolites via LC-MS/MS in pre-diagnostic plasma collected a mean of 10.3 years before POAG diagnosis. A cross-sectional analysis in the UK Biobank measured 168 metabolites via NMR spectroscopy in 2,238 prevalent glaucoma cases and 44,723 controls. Higher levels of diglycerides and triglycerides were adversely associated with incident POAG in all three US cohorts, with stronger associations observed for POAG with paracentral visual field loss, and these adverse associations were confirmed in the UK Biobank. The study is notable for its large sample size relative to prior metabolomics studies of glaucoma and use of pre-diagnostic plasma unaffected by manifest disease or treatment. Limitations include that the metabolomics platforms did not overlap substantially between the US cohorts and the UK Biobank, and the UK Biobank analysis was cross-sectional rather than prospective.
