PLOS ONE · 10 authors, 3 centres
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A polypharmacology approach identified seven drugs (dihydroergotamine, ergotamine, bisdequalinium chloride, midostaurin, temoporfin, tirilazad, venetoclax) that bind to multiple SARS-CoV-2 targets, suggesting potential to counter viral mutations.
A polypharmacology approach identified seven drugs (dihydroergotamine, ergotamine, bisdequalinium chloride, midostaurin, temoporfin, tirilazad, venetoclax) that bind to multiple SARS-CoV-2 targets, suggesting potential to counter viral mutations. Scaffold analysis identified common molecular scaffolds among high-scoring drugs. Pathway analysis of genes related to these multi-target drugs implicated biological processes like cell cycle regulation, signaling, and immune response, which are relevant to SARS-CoV-2 infection.
