Molecules · 8 authors, 4 centres
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This preclinical study analyzed longan byproduct polyphenol extracts (LPPE) for antioxidant activity and tested their effects on lipid metabolism in high-fat diet-induced obese mice. LPPE reduced body weight gain and improved lipid profiles, but findings are limited to animal models and require human validation.
Longan byproducts are rich in polyphenols, and lipid metabolism disorders are risk factors for chronic diseases. Polyphenols may regulate lipid metabolism, but the effects of longan byproduct polyphenol extracts (LPPE) were not previously investigated. Methods: Polyphenols were extracted from longan byproducts and analyzed via UPLC-QqQ-MS/MS. Antioxidant activity was evaluated in vitro using DPPH, ABTS, and FRAP assays. In vivo, high-fat diet-induced obese mice were treated with LPPE for 12 weeks (n=8 per group). Body weight, serum and liver lipids, histology, and gene/protein expression were measured. Key Results: LPPE showed high antioxidant activity (e.g., DPPH: 231.350 ± 21.640 mg Vc/g). In mice, LPPE supplementation reduced body weight gain by 11.8% compared to the HFD group, decreased serum and liver lipids, improved hepatic steatosis, and upregulated PPARα and LXRα expression, affecting target genes like FAS, CYP7A1, and CYP27A1. Limitations: This is a preclinical animal study with a small sample size, and the mechanisms need further investigation. Implications: LPPE could serve as a dietary supplement for improving lipid metabolism, but human clinical trials are necessary to confirm efficacy and safety.
