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RCT·endocrinology, nutrition, clinical nutrition, internal medicine, clinical trial·PMC10451960

Poplar Propolis Improves Insulin Homeostasis in Non-Diabetic Insulin-Resistant Volunteers with Obesity: A Crossover Randomized Controlled Trial

Antioxidants · 5 authors, 2 centres

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FIDELITY 100%

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TL;DR

This crossover randomized controlled trial tested standardized poplar propolis supplementation for three months in non-diabetic, insulin-resistant volunteers with obesity.

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This crossover randomized controlled trial investigated the effect of standardized poplar propolis extract powder (PPEP) supplementation, individually dosed to 6 mg total polyphenols/kg, for three months in non-diabetic, insulin-resistant volunteers with obesity. The authors note that the improvements were not attributed to changes in BMI, body fat, or waist circumference. Limitations include imperfect compliance with daily capsule intake and the potential, though considered minimal, effects of the placebo components (maltodextrin and carob powder).

STUDY TYPE

RCT

SPECIALTY

endocrinology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10451960

Poplar Propolis Improves Insulin Homeostasis in Non-Diabetic Insulin-Resistant Volunteers with Obesity: A Crossover Randomized Controlled Trial

Antioxidants

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ABSTRACT

Abstract Propolis, a natural resinous mixture rich in polyphenols, produced by bees from a variety of plant sources, has shown significant therapeutic effects and may prevent the development of certain chronic diseases like type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate the effect of supplementation with standardized poplar propolis extract powder (PPEP) on insulin homeostasis in non-diabetic insulin-resistant volunteers with obesity. In this randomized, controlled, crossover trial, nine non-diabetic insulin-resistant volunteers with obesity, aged 49 ± 7 years, were subjected to two periods of supplementation (placebo and PPEP) for 3 months. Blood samples and anthropomorphic data were collected at baseline and at the end of each phase of the intervention. PPEP supplementation improved insulin sensitivity by significantly decreasing the percentage of insulin-resistant subjects and the insulin sensitivity Matsuda index (ISI-M). According to this study, supplementation with standardized PPEP for 3 months in non-diabetic insulin-resistant volunteers with obesity led to an improvement in insulin homeostasis by its effect on insulin resistance and secretion. This study suggests that poplar propolis has a preventive effect on the physiopathological mechanisms of T2DM and, therefore, that it can help to prevent the development of the disease. Keywords: propolis, insulin resistance, type 2 diabetes mellitus, glucose homeostasis, polyphenols, insulin secretion, oral glucose tolerance test, preventive nutrition, insulin sensitivity Matsuda index

CITATION EXPORT

Lea Sani, Nicolas Cardinault, Julien Astier et al.. Poplar Propolis Improves Insulin Homeostasis in Non-Diabetic Insulin-Resistant Volunteers with Obesity: A Crossover Randomized Controlled Trial. Antioxidants. (2023). https://doi.org/10.3390/antiox12081481

AUTHORS

5 · 2 CENTRES

Lea Sani, Nicolas Cardinault, Julien Astier, Patrice Darmon, Jean François Landrier

1Centre for Nutrition and Cardiovascular Disease (C2VN), INSERM, INRAE, AIX Marseille University, 13000 Marseille, France; [email protected] (L.S.); [email protected] (J.A.); [email protected] (P.D.)
2Association Francophone d’Apithérapie, 58300 Decize, France; [email protected]