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other·ophthalmology, retina, pediatric ophthalmology, nutrition, preclinical research·PMC10568433

Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)

iScience · 11 authors, 5 centres

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TL;DR

The study combined preclinical mouse experiments with a retrospective analysis of human clinical data.

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The study combined preclinical mouse experiments with a retrospective analysis of human clinical data. In a mouse model of hyperglycemia-associated Phase I ROP, the authors found that hyperglycemia significantly altered retinal amino acid levels, including a decrease in branched-chain amino acids. Parenteral supplementation of L-isoleucine worsened the suppression of physiological retinal vessel growth. Multivariable logistic regression, adjusting for treatment group, gestational age, birth weight, and sex, showed that the number of days on parenteral amino acid support independently predicted severe ROP.

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other

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ophthalmology

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ORIGINAL PAPER

PMC10568433

Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)

iScience

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ABSTRACT

Summary Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Amino acid supplementation reduces retinal neovascularization in mice. Little is known about amino acid contribution to Phase I ROP. In mice modeling hyperglycemia-associated Phase I ROP, we found significant changes in retinal amino acids (including most decreased L-leucine, L-isoleucine, and L-valine). Parenteral L-isoleucine suppressed physiological retinal vascularization. In premature infants, severe ROP was associated with a higher mean intake of parenteral versus enteral amino acids in the first two weeks of life after adjustment for treatment group, gestational age at birth, birth weight, and sex. The number of days with parenteral amino acids support independently predicted severe ROP. Further understanding and modulating amino acids may help improve nutritional intervention and prevent Phase I ROP.

CITATION EXPORT

Jarrod C. Harman, Aldina Pivodic, Anders K. Nilsson et al.. Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP). iScience. (2023). https://doi.org/10.1016/j.isci.2023.108021

AUTHORS

11 · 5 CENTRES

Jarrod C. Harman, Aldina Pivodic, Anders K. Nilsson, Myriam Boeck, Hitomi Yagi, Katherine Neilsen, Minji Ko, Jay Yang, Michael Kinter, Ann Hellström, Zhongjie Fu

1Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
2The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
3Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany
4Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan
5Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA