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TL;DR
Fructose produced lower postprandial blood glucose than glucose but significantly increased uric acid and malondialdehyde levels.
Archives of Endocrinology and Metabolism · 6 authors, 2 centres
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Fructose produced lower postprandial blood glucose than glucose but significantly increased uric acid and malondialdehyde levels.
Blood samples were drawn after 8h fasting and at 180 min postprandial. Fructose resulted in significantly lower postprandial blood glucose than glucose (4.4 ± 5.5 mmol/L versus 12.9 ± 4.1 mmol/L; p < 0.01). Uric acid increased after fructose (26.1 ± 49.9 µmol/L; p < 0.01) and decreased after glucose (-13.6 ± 9.5 µmol/L; p < 0.01). Malondialdehyde increased after fructose (1.4 ± 1.6 µmol/L; p < 0.01) but did not change after glucose. The authors noted limitations including small sample size, convenience sampling, lack of glycosuria assessment, wide inter-patient variability, and that only acute effects were evaluated. The findings suggest fructose may raise oxidative stress and hyperuricemia risk in T1DM patients despite its lower glycemic impact.