SEARCHSYSTEMATIC_REVIEWcardiology, surgery

systematic_review·cardiology, surgery, preclinical research, systematic review, biomedical research·PMC10201874

Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review

Current Cardiology Reviews · 6 authors, 2 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

The review synthesized the evidence to provide a framework for future preclinical research.

Full summary

390 CHARS

The analysis included three acute and nine chronic studies. The studies evaluated various valve types (stented and stentless, trileaflet, unileaflet, and bileaflet) and outcomes like hemodynamic performance and calcification. The review acknowledges limitations such as the lack of a standardized reporting method for preclinical outcomes and the inherent differences between animal models.

STUDY TYPE

systematic_review

SPECIALTY

cardiology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10201874

Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review

Current Cardiology Reviews

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ABSTRACT

Abstract Background The development of atrioventricular bioprosthesis has witnessed an increasing drive toward clinical translation over the last few decades. A significant challenge in the clinical translation of an atrioventricular bioprosthesis from bench to bedside is the appropriate choice of a large animal model to test the safety and effectiveness of the device. Methods We conducted a systematic review of pre-clinical in vivo studies that would enable us to synthesize a recommended framework. PRISMA (Preferred Reporting Items for Systematic Reviews and MetaAnalyses) guidelines were followed to identify and extract relevant articles. Results Sheep was the most common choice of animal, with nine out of the 12 included studies being conducted on sheep. There were acute and chronic studies based on our search criteria. An average of ~20 and 5 animals were used for chronic and acute studies. One out of three acute studies and eight out of nine chronic studies were on stented heart valve bioprosthesis. All analyses were conducted on the implantation of atrioventricular valves with trileaflet, except for one chronic study on unileaflet valves and one chronic and acute study on bileaflet valves. Conclusion Understanding the variance in past pre-clinical study designs may increase the appropriate utilization of large animal models. This synthesized evidence provides a pre-clinical in vivo studies framework for future research on an atrioventricular bioprosthesis. Keywords: Bioprosthesis, atrioventricular valve, mitral bioprosthesis, tricuspid, hydrodynamic, large animal, in vivo , pre-clinical

CITATION EXPORT

Faizus Sazzad, Ramanathan Kollengode, Chan Li Xuan Beverly et al.. Preclinical Large Animal In-Vivo Experiments for Surgically Implanted Atrioventricular Valve: Reappraisal and Systematic Review. Current Cardiology Reviews. (2023). https://doi.org/10.2174/1573403X18666220617115216

AUTHORS

6 · 2 CENTRES

Faizus Sazzad, Ramanathan Kollengode, Chan Li Xuan Beverly, Tan Ying Kiat, Geetha Ganesh, Theo Kofidis

1Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore;
2Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Center, Kent Ridge, Singapore