PLOS ONE · 11 authors, 7 centres
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This is a protocol for a planned systematic review and meta-analysis to quantify premature cardiovascular disease mortality using indicators like years of life lost (YLL), age-standardized mortality rates (ASMR), and standardized mortality ratios (SMR). The central aim is to provide updated global estimates to inform public health policy.
The planned review will include observational studies reporting premature CVD mortality using YLL, ASMR, or SMR. The authors will search multiple databases, have two reviewers independently select studies and assess quality, and perform random-effects meta-analysis. Planned analyses include assessment of heterogeneity, publication bias, and subgroup analyses by sex, geography, CVD type, and study time. The protocol emphasizes the public health importance of estimating premature CVD mortality to track progress towards Sustainable Development Goal target 3.4. Key strengths include a meticulous design and inclusion of studies from low- and middle-income countries. Anticipated limitations include potential high heterogeneity and the inherent biases of observational studies.
