Premenarchal anorexia nervosa: clinical features, psychopharmacological interventions, and rehospitalization analysis in a 1-year follow-up, controlled study
European Journal of Pediatrics · 4 authors, 2 centres
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This retrospective controlled cohort study compared clinical features, psychopharmacological interventions, and 1-year rehospitalization rates in premenarchal versus postmenarchal patients hospitalized for anorexia nervosa. Age at admission and day hospital treatment level significantly predicted rehospitalization, but premenarchal status was not an independent predictor.
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A total of 43 premenarchal AN cases were included, described as one of the largest premenarchal AN samples in the literature. All patients received multidisciplinary hospital treatment including psychotherapy and nutritional interventions, with psychopharmacological treatment variables assessed via chart review. A predictive model for rehospitalization 1 year after discharge identified age at admission and day hospital treatment level as significant predictors, but prepubertal/pubertal status was not. Premenarchal patients had lower LH levels and lower SAFA-D depression scores than postmenarchal patients. SSRI use was lower in the premenarchal group (62.8% vs 80.1%). Limitations include the retrospective design, monocentric setting, and relatively short follow-up period.
