Precision Nutrition · 1 author, 2 centres
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This narrative review discusses the Developmental Origins of Health and Disease (DOHaD) paradigm and summarizes three prospective cohort studies from the Boston Birth Cohort, which found associations between prenatal nutrition (BMI patterns, pantothenate levels, Mediterranean-style diet) and child health outcomes.
This narrative review discusses the DOHaD paradigm, which posits that early life environmental factors, especially nutrition, significantly influence lifelong health and risk for chronic diseases. The author summarizes three prospective studies from the Boston Birth Cohort: one found distinct childhood BMI patterns predictable from early life; another associated higher cord blood pantothenate with increased risk of ASD and ADHD; and a third found maternal Mediterranean-style diet protective against child neurodevelopmental disabilities, particularly in mothers with metabolic disturbances. The review emphasizes nutrition as a key modifiable factor and calls for future research using nutritional biomarkers, precision nutrition approaches, and diverse populations. It highlights that findings support associations but notes research gaps remain.
