Scientific Reports · 7 authors, 5 centres
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This retrospective cohort study of patients with malignant pleural mesothelioma undergoing extrapleural pneumonectomy found that a higher preoperative neutrophil-to-lymphocyte ratio (NLR) was an independent predictor of worse 5-year overall survival. The study also identified correlations between NLR and PD-L1 expression in immune cells within the tumor microenvironment.
The study evaluated five preoperative inflammatory/nutritional parameters (NLR, PNI, CRP-to-albumin ratio, C/NLR, and LMR) and their correlation with PD-L1 expression in immune cells (IC) and tumor cells (TC) of the tumor microenvironment. The central finding from multivariate analysis was that a high NLR was an independent prognostic factor for poor 5-year overall survival. The study also found that the PD-L1 IC score was positively correlated with NLR and platelet count, while the PD-L1 TC score was inversely correlated with PNI and LMR. Limitations include the small sample size due to the rarity of the condition. The study suggests preoperative NLR testing could be a simple, low-cost prognostic tool for surgical candidates.
