Clinical and Translational Gastroenterology · 5 authors, 2 centres
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This retrospective cohort study of 124 patients with Crohn's disease found that a low preoperative Prognostic Nutritional Index (PNI) was a significant predictor of postoperative complications after bowel surgery. A prognostic nomogram incorporating PNI was developed to estimate the risk of these complications.
This retrospective cohort study analyzed 124 patients with Crohn's disease who underwent primary bowel surgery between January 2013 and October 2019. Patients were grouped by a preoperative PNI cutoff of 34. The low-PNI group had significantly lower serum albumin and hemoglobin levels, and a higher white blood cell count, compared to the high-PNI group. The primary finding was a significantly higher rate of postoperative complications in the low-PNI group (51.3%) compared to the high-PNI group (17.6%). A prognostic nomogram was developed using LASSO regression, identifying sex, BMI, myopenia, age, surgical indication, Harvey-Bradshaw Index (HBI), and PNI as risk factors. Limitations include the retrospective design, limited sample size, potential influence of preoperative treatments on PNI, and the need for external validation of the nomogram.
