SEARCHCOHORTpediatrics, infectious disease

cohort·pediatrics, infectious disease, critical care, epidemiology, observational study·PMC10589512

Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia

Medicine · 7 authors, 4 centres

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AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

It found MRSA was the most common pathogen (30.7%) and identified mechanical ventilation, invasive operations, and total parenteral nutrition as significant risk factors for mortality.

Full summary

124 CHARS

The population included 36.4% neonates and 63.6% pediatric patients. Urinary tract infection was the most common site (35%).

STUDY TYPE

cohort

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10589512

Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia

Medicine

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ABSTRACT

Successful empirical antibiotic therapy for infected patients with multi drug resistant bacteria (MDR) can be challenging task in various healthcare settings, including neonatal and pediatric intensive care units (NICU and PICU, respectively), unless an up-to-date comprehensive local antibiogram data is available. Thus, this project aimed to investigate the prevalence of MDR among PICU and NICU patients as well as the identification of risk factors associated with recovered MDR bacteria. This was a retrospective study of PICU and NICU patients admitted with bacterial infection of MDR organisms between October 2020 and May 2021. Frequency distribution, Chi-square test were applied to verify the significance differences among subgroups and to identify risk factor associated with each group. About 36.4% of recruited patients were neonates, while the remaining percentage (63.6%) were pediatric. The most predominant site of infection among these patients were revealed as urinary tract (35%), followed by bloodstream (20.0%), wound/skin (12.9%) and respiratory system (11.4%). Methicillin-resistant Staphylococcus aureus (MRSA) was identified as the most common microbe across these sites of infections (30.7%), followed by Escherichia coli (25.0%) , Klebsiella pneumoniae (22.9%) and Serratia (10.0%). High mortality rate was significantly associated with patients who were on mechanical ventilators (28.9%, OR 5.5; 95% CI), followed by patients had invasive operation (27.5%, OR, 8.04; 95% CI) and those who required a total parental nutrition (TPN) since almost one-half of these cases have (46.2%) died. In addition, mortality rate was relatively higher among patients infected with species of Serratia (28.6%) and Enterobacter (20.0%). These data highlighted that MRSA was the main MDR bacteria isolated from PICU and NICU followed by gram-negative bacteria, which were associated with high mortality rate. Therefore, infection control measures and continuous monitoring of emerging MDR bacteria should be applied to limit the bacterial infections in NICU and PICU patients.

CITATION EXPORT

Abdulrahman S. Bazaid, Abdu Aldarhami, Nada A. Bokhary et al.. Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia. Medicine. (2023). https://doi.org/10.1097/MD.0000000000035638

AUTHORS

7 · 4 CENTRES

Abdulrahman S. Bazaid, Abdu Aldarhami, Nada A. Bokhary, Mohammed B. Bazaid, Mohammad F. Qusty, Thamer H. AlGhamdi, Abdullatif A. Almarashi

a Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia
b Medical Microbiology, Qunfudah Faculty of Medicine, Umm Al-Qura University, AL-Qunfudah, Saudi Arabia
c Pediatric Department, East Jeddah Hospital, Jeddah, Saudi Arabia
d Jeddah Health Affairs, Jeddah, Saudi Arabia.

Abdulrahman S. Bazaid, Abdu Aldarhami, Nada A. Bokhary et al.. Prevalence and risk factors associated with drug resistant bacteria in neonatal and pediatric intensive care units: A retrospective study in Saudi Arabia. Medicine. (2023). https://doi.org/10.1097/MD.0000000000035638