SEARCHMETA-ANALYSISophthalmology, dry eye

meta-analysis·ophthalmology, dry eye, epidemiology, systematic review, meta-analysis·PMC10829227

Prevalence of dry eye and Meibomian gland dysfunction in Central and South America: a systematic review and meta-analysis

BMC Ophthalmology · 11 authors, 4 centres

AI SUMMARY

FIDELITY 100%

POPULATIONGeneral and subpopulations (indoor workers, students, ophthalmology clinic patients) in Central and South America

INTERVENTION

COMPARISON

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

A systematic review and meta-analysis of 14 studies found that dry eye prevalence in Central and South America ranged from 13% in the general Brazilian population to 83% in ophthalmology clinic-based populations, with high estimates also observed in student and indoor worker subgroups.

Full summary

856 CHARS

This systematic review and meta-analysis included 14 studies with 11,594 total participants to estimate dry eye and MGD prevalence in Central and South America. Data sources were Ovid MEDLINE and Embase, with searches conducted through August 16, 2021. Population-level dry eye prevalence was 13% in Brazil and 41% in Mexico based on one study each, with considerable statistical heterogeneity preventing pooling. Meta-analyses of subpopulations showed pooled dry eye prevalence of 70% among indoor workers, 71% among students, and 83% in general ophthalmology clinics. MGD prevalence ranged from 23% among indoor workers to 68% in general ophthalmology clinics, each based on a single study. Considerable clinical and methodological heterogeneity was noted across studies, attributable to different diagnostic criteria, age ranges, and geographic regions.

PICO

PPOPULATION

General and subpopulations (indoor workers, students, ophthalmology clinic patients) in Central and South America

OOUTCOME

Prevalence of dry eye and Meibomian gland dysfunction

STUDY TYPE

meta-analysis

SPECIALTY

ophthalmology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10829227

Prevalence of dry eye and Meibomian gland dysfunction in Central and South America: a systematic review and meta-analysis

BMC Ophthalmology

READ THE FULL PAPER

ABSTRACT

Background Dry eye is one of the most common ophthalmic conditions and can significantly impact quality of life. Meibomian gland dysfunction (MGD) is a major cause of evaporative dry eye. We sought to conduct a systematic review and meta-analysis to estimate the prevalence and incidence of dry eye and MGD in Central and South America and to identify factors associated with disease burden. Methods Data sources Ovid MEDLINE and Embase. Study selection A search conducted on August 16, 2021, identified studies published between January 1, 2010, and August 16, 2021, with no restrictions regarding participant age or language of publication. Case reports, case series, case–control studies, and interventional studies were excluded. Data extraction and synthesis The review was based on a protocol registered on PROSPERO (CRD42021256934). Risk of bias was assessed in duplicate using a risk of bias tool designed for the purposes of descriptive epidemiological studies. Data were extracted by one investigator and verified by another for accuracy. Prevalence of dry eye and MGD were grouped based on study participant characteristics. Main outcomes and measures Prevalence and incidence of dry eye and MGD in Central and South America. Summary estimates from meta-analysis with 95% confidence intervals (CI). Results Fourteen studies (11,594 total participants) were included. The population prevalence of dry eye was 13% (95% CI, 12%-14%) in Brazil and 41% (95% CI, 39%-44%) in Mexico based on one study each. Meta-analyses suggested that dry eye prevalence was 70% among indoor workers (95% CI, 56%-80%; I 2 , 82%; 3 studies), 71% among students (95% CI, 65%-77%; I 2 , 92%; 3 studies), and 83% in general ophthalmology clinics (95% CI, 77%-88%; I 2 , 88%; 2 studies). MGD prevalence ranged from 23% among indoor workers (95% CI, 16%-31%; 1 study) to 68% in general ophthalmology clinics (95% CI, 62%-72%; 1 study). No studies reported incidence of dry eye or MGD. Conclusions This systematic review and meta-analysis demonstrated considerable variation in the published prevalence of dry eye and MGD among the general population and subpopulations in Central and South America. Local and subpopulation estimates of dry eye disease burden may be valuable to assist needs assessments and implementation of measures to mitigate the condition. Supplementary Information The online version contains supplementary material available at 10.1186/s12886-023-03249-w.

CITATION EXPORT

Hongan Chen, Paul McCann, Tiffany Lien et al.. Prevalence of dry eye and Meibomian gland dysfunction in Central and South America: a systematic review and meta-analysis. BMC Ophthalmology. (2024). https://doi.org/10.1186/s12886-023-03249-w

AUTHORS

11 · 4 CENTRES

Hongan Chen, Paul McCann, Tiffany Lien, Mengli Xiao, Alison G. Abraham, Darren G. Gregory, Scott G. Hauswirth, Riaz Qureshi, Su-Hsun Liu, Ian J. Saldanha, Tianjing Li

1https://ror.org/03wmf1y16grid.430503.10000 0001 0703 675XDepartment of Ophthalmology, University of Colorado Anschutz Medical Campus, 1675 Aurora Ct, Aurora, CO F731 USA
2https://ror.org/005x9g035grid.414594.90000 0004 0401 9614Department of Epidemiology, Colorado School of Public Health, Aurora, CO USA
3https://ror.org/005x9g035grid.414594.90000 0004 0401 9614Center for Innovative Design & Analysis, Colorado School of Public Health, Aurora, CO USA
4grid.21107.350000 0001 2171 9311Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA