SEARCHCROSS-SECTIONALepidemiology, public health

cross-sectional·epidemiology, public health, oncology, endocrinology, nutrition·PMC10473473

Prevalence, trend and associated factors of obesity-related cancers among U.S. adults with metabolic syndrome: Evidence from the National Health and Nutrition Examination Survey 2001–2018

PLOS ONE · 7 authors, 5 centres

AI SUMMARY

FIDELITY 100%

POPULATIONU.S. adults aged ≥20 years with metabolic syndrome from NHANES 2001–2018

INTERVENTION

COMPARISONORC vs non-ORC within subgroups; three time periods (2001–2006, 2007–2012, 2013–2018)

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This cross-sectional study of NHANES 2001–2018 data estimated the prevalence of obesity-related cancers at 35.8% among U.S. adults with metabolic syndrome, finding significantly higher odds among females, Hispanics, non-Hispanic Blacks, and older adults, with a stable overall temporal trend but increasing trends for thyroid, uterine, colorectal, and ovarian cancers.

Full summary

922 CHARS

This cross-sectional study analyzed NHANES 2001–2018 data to estimate prevalence, associated factors, and temporal trends of obesity-related cancers (ORCs) among U.S. adults with metabolic syndrome (MetS) aged ≥20 years. Multivariable logistic regression revealed higher odds of ORC among females (OR=7.1), Hispanics (OR=2.9), non-Hispanic Blacks (OR=2.7), and adults aged ≥60 years (OR=5.4) compared to their respective reference groups. The six most prevalent individual ORCs were thyroid (10.95%), breast (10%), uterine (9.18%), colorectal (7.86%), ovarian (5.74%), and stomach (0.80%). Age-standardized prevalence remained stable across three time periods (30.6%, 30.3%, 30.7%), though increasing trends were noted for thyroid, uterine, colorectal, and ovarian cancers while breast cancer decreased. The cross-sectional design limits causal inference, and dietary changes and quality-of-life factors were not examined.

PICO

PPOPULATION

U.S. adults aged ≥20 years with metabolic syndrome from NHANES 2001–2018

OOUTCOME

Prevalence of obesity-related cancers, associated sociodemographic and behavioral factors, and temporal trends

STUDY TYPE

cross-sectional

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10473473

Prevalence, trend and associated factors of obesity-related cancers among U.S. adults with metabolic syndrome: Evidence from the National Health and Nutrition Examination Survey 2001–2018

PLOS ONE

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ABSTRACT

Abstract Introduction This study evaluated the prevalence, associated factors and trends in the prevalence of obesity-related cancer (ORC) among U.S. adults with metabolic syndrome (MetS) and age ≥20 years. Methods This study used cross-sectional data from the 2001–2018 National Health and Nutrition Examination Survey. The total period analyses included prevalence estimation, chi-square tests for comparing ORC vs non-ORC within subgroups, and a multivariable-logistic regression model to evaluate associated factors of ORC. For trend analysis, the total period was divided into three time periods: 2001–2006, 2007–2012 and 2013–2018. Age-standardized prevalence of ORC in each time period was calculated. Results The ORC prevalence was 35.8% representing 4463614 adults with MetS. A higher odds of ORC was observed among females (OR = 7.1, 95% CI = 4.9–10.3) vs males, Hispanic (OR = 2.9, 95% CI = 1.7–4.8) and non-Hispanic Black (OR = 2.7, 95% CI = 1.8–4) vs non-Hispanic White, age ≥60 (OR = 5.4, 95% CI = 1.9–15.4) vs age 20–39 years. Individual ORCs were thyroid (10.95%), breast (10%), uterine (9.18%), colorectal (7.86%), ovarian (5.74%), and stomach (0.80%). The age-standardized prevalence of ORC was observed stable in three time periods (30.6%, 30.3% and 30.7%). However, an increasing trend was seen for thyroid, uterine, colorectal and ovarian cancers while decreasing trend for breast cancer. Hispanic people showed a significant increasing trend of ORC (p = 0.004). Conclusions ORC was found significantly higher among female, Hispanic, non-Hispanic black and older people with MetS. The stable temporal trend of overall ORC, with an increasing trend in certain ORCs, makes the disease spectrum a public health priority. The findings imply the importance of intensifying efforts to reduce the burden of MetS comorbidities among U.S. adults.

CITATION EXPORT

Harun Mazumder, Maidul Husain, Md Faruk Hossain et al.. Prevalence, trend and associated factors of obesity-related cancers among U.S. adults with metabolic syndrome: Evidence from the National Health and Nutrition Examination Survey 2001–2018. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0290994

AUTHORS

7 · 5 CENTRES

Harun Mazumder, Maidul Husain, Md Faruk Hossain, Sultan Mahmud, Meisam Akhlaghdoust, Meisam Akhlaghdoust, Meisam Akhlaghdoust

1Institute of Statistical Research and Training, University of Dhaka, Dhaka, Bangladesh
2School of Public Health, Louisiana State University Health Sciences Center-New Orleans, New Orleans, Louisiana, United States of America
3Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
4International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
5Shahid Beheshti University of Medical Sciences, ISLAMIC REPUBLIC OF IRAN