SEARCHNARRATIVE_REVIEWnutrition, neurology

narrative_review·nutrition, neurology, epidemiology, dietetics, systematic review·PMC10539673

Prevention of Alzheimer's disease through diet: An exploratory review

Metabolism Open · 5 authors, 3 centres

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TL;DR

This exploratory narrative review analyzed the relationship between dietary patterns (Mediterranean, DASH, MIND), nutritional components, and Alzheimer's disease (AD) risk and biomarkers.

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This exploratory narrative review analyzed the relationship between dietary patterns (Mediterranean, DASH, MIND), nutritional components, and Alzheimer's disease (AD) risk and biomarkers. The authors searched multiple databases and presented data from existing studies, including meta-analyses and clinical trials.

STUDY TYPE

narrative_review

SPECIALTY

nutrition

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100% · A

ORIGINAL PAPER

PMC10539673

Prevention of Alzheimer's disease through diet: An exploratory review

Metabolism Open

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ABSTRACT

Introduction This exploratory review article describes about the genetic factors behind Alzheimer's disease (AD), their association with foods, and their relationships with cognitive impairment. It explores the dietary patterns and economic challenges in AD prevention. Methods Scopus, PubMed and Google Scholar were searched for articles that examined the relationships between Diets, Alzheimer's Disease (AD), and Socioeconomic conditions in preventative Alzheimer's disease studies. Graphs and Network analysis data were taken from Scopus under the MeSH search method, including words, Alzheimer's, APoE4, Tau protein, APP, Amyloid precursor protein, Beta-Amyloid, Aβ, Mediterranean Diet, MD, DASH diet, MIND diet, SES, Socioeconomic, Developed country, Underdeveloped country, Preventions. The network analysis was done through VOS viewer. Results Mediterranean diet (MD) accurately lowers AD (Alzheimer's Disease) risk to 53% and 35% for people who follow it moderately. MIND scores had a statistically significant reduction in AD rate compared to those in the lowest tertial (53% and 35% reduction, respectively). Subjects with the highest adherence to the MD and DASH had a 54% and 39% lower risk of developing AD, respectively, compared to those in the lowest tertial. Omega-6, PUFA, found in nuts and fish, can play most roles in the clearance of Aβ. Vitamin D inhibits induced fibrillar Aβ apoptosis. However, the high cost of these diet components rise doubt about the effectiveness of AD prevention through healthy diets. Conclusion The finding of this study revealed an association between diet and the effects of the chemical components of foods on AD biomarkers. More research is required to see if nutrition is a risk or a protective factor for Alzheimer's disease to encourage research to be translated into therapeutic practice and to clarify nutritional advice.

CITATION EXPORT

Nusrat Zahan Bhuiyan, Md. Kamrul Hasan, Zimam Mahmud et al.. Prevention of Alzheimer's disease through diet: An exploratory review. Metabolism Open. (2023). https://doi.org/10.1016/j.metop.2023.100257

AUTHORS

5 · 3 CENTRES

Nusrat Zahan Bhuiyan, Md. Kamrul Hasan, Zimam Mahmud, Md. Sabbir Hossain, Atiqur Rahman

aDepartment of Biochemistry and Molecular Biology, National University Bangladesh, Gazipur, 1704, Bangladesh
bDepartment of Public Health, North South University, Dhaka, 1229, Bangladesh
cDepartment of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 1000, Bangladesh