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TL;DR
A dichloromethane-methanol extract of the SaTRN7.1 hairy root line showed protective activity against ethanol-induced gastric ulcers in an animal model.
Plants · 8 authors, 3 centres
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A dichloromethane-methanol extract of the SaTRN7.1 hairy root line showed protective activity against ethanol-induced gastric ulcers in an animal model.
This study employed hairy root cultures (lines SaTRN12.2 and SaTRN7.1) of Sphaeralcea angustifolia to produce anti-inflammatory and immunomodulatory compounds, including scopoletin, sphaeralcic acid, stigmasterol, and β-sitosterol. The protective activity of the dichloromethane-methanol extract of the SaTRN7.1 hairy root line was evaluated against ethanol-induced gastric ulcers in an animal model, and this extract was found to confirm the traditional use of S. angustifolia for gastrointestinal illness. The authors noted that stable and enhanced active compound production from the SaTRN7.1 culture could be scaled up using a bioreactor.