Prognostic significance of index (LANR) composed of preoperative lymphocytes, albumin, and neutrophils in patients with stage IB-IIA cervical cancer

PLOS ONE · 9 authors, 3 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

High preoperative LANR was independently associated with significantly better overall survival and progression-free survival.

Full summary

770 CHARS

Thirteen clinicopathological variables and three systemic inflammatory parameters were evaluated alongside the LANR index. ROC analysis determined cut-off values for LANR, which achieved an AUC of 0.704 for overall survival and 0.745 for progression-free survival. Univariate and multivariate analyses showed LANR was independently associated with both OS and PFS (p<0.05). Kaplan-Meier analysis demonstrated that patients with high LANR levels had significantly higher OS and PFS than those with low levels (p<0.001 for both). Individual parameters (albumin, lymphocytes, neutrophils) were associated with survival in univariate analysis but were not independent prognostic factors in multifactorial analysis. A large prospective multicenter validation study is needed.

STUDY TYPE

cohort

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10511094

Prognostic significance of index (LANR) composed of preoperative lymphocytes, albumin, and neutrophils in patients with stage IB-IIA cervical cancer

PLOS ONE

READ THE FULL PAPER

ABSTRACT

Background The purpose of this study was to investigate the role of preoperative lymphocytes, albumin, neutrophils, and LANR in the prognosis of patients with stage IB-IIA cervical cancer (CC). Methods We made a retrospective analysis of the clinical information and related materials of 202 patients with stage IB-IIA primary cervical cancer who had undergone a radical hysterectomy in the Department of Gynecology at the Affiliated Hospital of Jiangnan University between January 2017 and December 2018. The definition of LANR was as follows: LANR, lymphocyte × albumin / neutrophil. The receiver operating characteristic curve (ROC) was generated to determine the best cut-off values for these parameters, as well as the sensitivity and specificity of LANR in predicting recurrence and survival. The Kaplan–Meier method was employed to draw survival curves in our survival analysis. Univariate analysis, multifactorial analysis, and subgroup analysis were used to evaluate the prognostic significance of LANR in overall and progression-free survival. Results The median follow-up time of the study was 55 months. In overall survival, the area under the curve for LANR was 0.704 (95% CI: 0.590–0.818, p<0 . 05 ). And in progression-free survival, the area under the curve for LANR was 0.745 (95% CI: 0.662–0.828, p <0.05). Univariate and multivariate analyses showed that the value of LANR was associated with both overall survival and progression-free survival ( p < 0.05). Kaplan-Meier analysis demonstrated that OS ( p < 0.001) and PFS ( p < 0.001) in patients with high LANR levels were significantly higher than those with low LANR levels. Conclusions Our findings suggested that LANR might serve as a clinically reliable and effective independent prognostic indicator in patients with stage IB-IIA cervical cancer.

CITATION EXPORT

Shan Wang, Yuan Wang, Jiaru Zhuang et al.. Prognostic significance of index (LANR) composed of preoperative lymphocytes, albumin, and neutrophils in patients with stage IB-IIA cervical cancer. PLOS ONE. (2023). https://doi.org/10.1371/journal.pone.0290905

AUTHORS

9 · 3 CENTRES

Shan Wang, Yuan Wang, Jiaru Zhuang, Yibo Wu, Weifeng Shi, Lei Wang, Federico Romano, Federico Romano, Federico Romano

1 Obstetrics, Gynecology and Reproduction Research, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, P.R. China
2 Department of General surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, P.R. China
IRCCS Burlo Garofolo Trieste, ITALY

EDITOR / REVIEWER

Federico Romano