Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis

BMC Gastroenterology · 7 authors, 1 centre

AI SUMMARY

FIDELITY 100%

POPULATIONColorectal cancer patients undergoing curative resection

INTERVENTIONNone; observational study of prognostic score

COMPARISONHigh-NPS vs. Low-NPS groups

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AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

The NPS had the highest area under the curve for predicting 5-year OS compared to other inflammation-based markers.

Full summary

419 CHARS

The NPS had the highest area under the curve for predicting 5-year OS compared to other inflammation-based markers. Subgroup analysis showed high-NPS was associated with worse OS across pStage I, II, and III disease. Limitations include the single-center retrospective design, lack of genetic data, and a homogeneous Japanese population. The findings suggest NPS may be a useful prognostic indicator for these patients.

PICO

PPOPULATION

Colorectal cancer patients undergoing curative resection

IINTERVENTION

None; observational study of prognostic score

OOUTCOME

Overall survival (OS) and disease-free survival (DFS)

STUDY TYPE

cohort

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10040130

Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis

BMC Gastroenterology

READ THE FULL PAPER

ABSTRACT

Background Systemic inflammation is recognized as a hallmark of cancer that contributes to tumor development and progression in various malignancies. The Naples prognostic score (NPS) was established as a prognostic indicator for colorectal cancer (CRC). This study aims to examine the predictive value of the NPS for survival in CRC patients undergoing curative resection by a propensity score matching (PSM) analysis. Methods A total of 533 CRC patients were enrolled in this study. Overall survival (OS) and disease-free survival (DFS) were compared between high-NPS and low-NPS groups. A time-dependent receiver operator characteristic (ROC) curve analysis was conducted to calculate the area under curve (AUC) of the NPS for OS. A multivariable Cox-proportional hazards regression analysis and PSM analysis were used to identify independent prognostic factors for OS and DFS. We compared the predictive value of the NPS to that of the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), Onodera prognostic nutritional index (PNI), and controlling nutritional status score (CONUT) for OS. Results High-NPS was significantly associated with worse OS and DFS. After PSM, 123 patients were included in each group. A multivariate analysis revealed that Age ≥ 68, ASA-PS ≥ 3, high NPS and undifferentiated tumor type were independently associated with OS, while high NPS, advanced T and N stage were independently associated with DFS after PSM. The NPS had the greatest AUC for OS in comparison to the NLR, LMR, PNI and CONUT. Conclusions We successfully validated the prognostic utility of the NPS for CRC patients after curative resection.

CITATION EXPORT

Atsushi Sugimoto, Tatsunari Fukuoka, Masatsune Shibutani et al.. Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis. BMC Gastroenterology. (2023). https://doi.org/10.1186/s12876-023-02722-6

AUTHORS

7 · 1 CENTRES

Atsushi Sugimoto, Tatsunari Fukuoka, Masatsune Shibutani, Hiroaki Kasashima, Kishu Kitayama, Masaichi Ohira, Kiyoshi Maeda

grid.258799.80000 0004 0372 2033Department of Gastroenterological Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-Ku, Osaka, 545-8585 Japan